Efficacy of health education on treatment of children with atopic dermatitis: a meta-analysis of randomized controlled t
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REVIEW
Efficacy of health education on treatment of children with atopic dermatitis: a meta‑analysis of randomized controlled trials Yunling Li1 · Ting Han2 · Wei Li1 · Yin Li1 · Xiaoxuan Guo1 · Lei Zheng1 Received: 11 January 2019 / Revised: 24 December 2019 / Accepted: 28 March 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Atopic dermatitis (AD) seriously affects the quality of life of children and their families. This meta-analysis aimed to comprehensively analyze health education on the treatment of children with AD and the quality of life of the patient’s family. A comprehensive search of reference lists in PubMed, Embase, Cochrane Library, Wanfang, CNKI, and VIP databases from inception until April 2018 was performed. The weighted mean difference (WMD) with 95% confidence interval (CI) was calculated. A total of eight randomized controlled trials studies were included in the analysis. The heterogeneity among enrolled studies was statistically significant, and the random effects model was used. The meta-analysis showed that the health education group had significantly lower SCORing Atopic Dermatitis (SCORAD) (WMD = 7.57 [95% CI 2.77, 12.36], P = 0.002 at 3 months; WMD = 6.88 [95% CI 2.68, 11.08], P = 0.001 at 6 months; WMD = 8.67 [95% CI 3.67, 13.67], P = 0.0007 at 12 months), objective SCORAD (WMD = 7.60 [95% CI 1.37, 13.83], P = 0.02 at 6 months; WMD = 5.15 [95% CI 1.89, 8.41], P = 0.002 at 12 months), and Infants’ Dermatology Quality of Life Index (WMD = 0.96 [95% CI 0.06, 1.86], P = 0.04 at 3 months, and WMD = 1.50 [95% CI 0.33, 2.67] at 6 months, P = 0.01) scores compared with the non-health education group. Health education could improve the treatment of children with AD and promote disease control. Keywords Health education · Children atopic dermatitis · Meta-analysis
Introduction Atopic dermatitis (AD) is the most common chronic relapsing inflammatory disease in children [1, 2]. The prevalence rates of AD in children have markedly increased in the past three decades, ranging from 10 to 30% [3–7]. AD significantly affect children and their families. Usually, children with AD may have problems such as sleep loss, anxiety, and fatigue [8–10]. Meanwhile, parents of children with AD may have guilt, sleep disturbance, fatigue, loneliness, frustration, distress, resentment, anxiety, anger, helplessness, and financial loss [11–13]. In patient with AD, it is widely
* Lei Zheng [email protected] 1
Department of Dermatology, Children’s Hospital, School of Medicine, University of Zhejiang, No. 3333 Binsheng Road, Hangzhou, Zhejiang, China
Department of Children’s Health Care, Children’s Hospital, School of Medicine, University of Zhejiang, Hangzhou, China
2
acknowledged that daily care plays an important role in the treatment of the disease [14]. In 1993, a task force of European experts published a scoring system known as the SCORing Atopic Dermatitis (SCORAD) [24], and the SCORAD index has been recognized as the most extensive test for the quality criteria [25]. Measu
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