Electro-Stimulated Release of Poorly Water-Soluble Drug from Poly(Lactic Acid)/Carboxymethyl Cellulose/ZnO Nanocomposite
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RESEARCH PAPER
Electro-Stimulated Release of Poorly Water-Soluble Drug from Poly(Lactic Acid)/Carboxymethyl Cellulose/ZnO Nanocomposite Film Thennakoon M. Sampath U. Gunathilake 1,2 & Yern Chee Ching 1,2 & Cheng Hock Chuah 3 & Nguyen Dai Hai 4,5 & Liou Nai-Shang 6 Received: 25 April 2020 / Accepted: 13 August 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
ABSTRACT Purpose Among various types of external stimuli-responsive DDS, electric-responsive DDS are more promising carriers as they exploit less complex, easily miniaturized electric signal generators and the possibility of fine-tuning the electric signals. This study investigates the use of intrinsically biocompatible biopolymers in electro-simulative drug delivery to enhance the release of poorly-soluble/non-ionic drug. Methods CMC/PLA/ZnO/CUR nanocomposite films were prepared by the dispersion of CMC and ZnO NPs in solubilized PLA/curcumin medium, followed by solvent casting step. Curcumin is poorly water-soluble and used as the model drug in this study. The films with different contents of CMC, PLA and ZnO NPs were characterized using FTIR, impedance spectroscopy, tensile testing and FESEM imaging. The in vitro drug release of the films was carried out in deionized water under DC electric field of 4.5 V.
Results The ionic conductivity of the films increased with increasing the CMC concentration of the film. The addition of a small amount of ZnO NPs (2%) successfully restored the tensile properties of the film. In response to the application of the electric field, the composite films released drug with a near-linear profile. There was no noticeable amount of passive diffusion of the drug from the film with the absence of the electric field. Conclusion The outcome of this study enabled the design of an electric-responsive nanocomposite platform for the delivery of poorly water-soluble/non-ionic drugs.
KEY WORDS biodegradable . carboxymethyl cellulose . curcumin . electro-stimulated . on-demand drug delivery . ZnO nanoparticle
Highlights Poly(lactic acid)/carboxymethyl cellulose/ZnO/curcumin nanocomposite film was prepared using solvent casting method. The emulsification and electrophoretic properties of carboxymethyl cellulose have been utilized for the electro-stimulated drug delivery process. The study demonstrates the approach to trigger the release of poorly watersoluble and non-ionic drugs under electric stimulation. The film does not show noticeable natural drug release providing that the total control of drug release under electrical stimulation. The biopolymers provide an alternative for the use of nondegradable conductive polymers in electro-simulative drug delivery systems. * Yern Chee Ching [email protected]
1
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Centre of Advanced Materials (CAM), Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia Department of Chemical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia
3
Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lump
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