Electrochemical Reaction Mechanism of Nitrofurazone at Poly-ACBK/GCE and Its Analytic Application
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ORIGINAL ARTICLE
Electrochemical Reaction Mechanism of Nitrofurazone at Poly‑ACBK/ GCE and Its Analytic Application Yanfang Wang1 · Ying Guo1 · Kunming Pan1 · Xiaoyun Lin1,2 · Yongnian Ni1 Received: 19 January 2020 / Accepted: 23 May 2020 © The Tunisian Chemical Society and Springer Nature Switzerland AG 2020
Abstract In this paper, an electrochemical sensor based on depositing acid chrome blue K on the surface of glassy carbon electrode was developed for detection of nitrofurazone. The obtained poly-ACBK film was characterised by atomic force microscope. The experimental results indicated that the Poly-ACBK/GCE showed good electrocatalytic activity to the redox reactions of nitrofurazone by differential pulse voltammetry and cyclic voltammetry in Britton-Robinson buffer solution, and the different redox peak currents were observed in different pH ranges (2.0–6.0, 7.0–12.0). Base on these, electrochemical reaction mechanism of nitrofurazone was presented in different pH ranges. Under the optimal conditions, a linear relationship between the reduction peak currents and concentrations for nitrofurazone is figured out in the range of 0.75‒192 μM, with detection limits of 0.25 µM (S/N = 3). This sensor produced satisfactory reproducibility and stability and was successfully applied to monitor of nitrofurazone in real samples (nasal drops). Keywords Nitrofurazone · Acid chrome blue K · Electrochemical reaction mechanism · Quantitative analysis
1 Introduction Nitrofurans (NFs), mainly including nitrofurazone (NFZ), furazolidone (FZD) and nitrofurantoin (NFT), belong to a series of chemically synthesized broad-spectrum, which are often used as veterinary drugs to treat bacterial and protozoan infections [1, 2]. After research, it was found that these antibacterial drugs could not only treat some diseases but also promote the growth of animals. So they have been misused in fish, shrimp, crab, poultry and swine as feed additives [3–6]. However, the residues of NFs and its metabolites were paid attention to threatening the human health because of their carcinogenic and teratogenic risk [7, 8]. Consequently, NFs compounds were prohibited as food and Electronic supplementary material The online version of this article (https://doi.org/10.1007/s42250-020-00150-7) contains supplementary material, which is available to authorized users. * Xiaoyun Lin [email protected] 1
College of Chemistry, Nanchang University, Nanchang 330031, China
Jiangxi Province Key Laboratory of Modern Analytical Science, Nanchang University, Nanchang 330031, China
2
animal production additives in the European Union (EU) (in 1995) and in the USA (in 2002) [9], and the European Commission has established the minimum required performance level (MRPL) at 1 µg kg−1 for NFs [10, 11]. Among these NFs drugs, NFZ is the most common and widely used one. Therefore, to develop a sensitive detection method of NFZ is of considerable importance. Some methods have been reported for the detection of NFs and their metabolites, such as high performance
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