Electron Microscopy of Axon Degeneration: A Valuable Tool in Experimental Neuroanatomy
Experimental methods for the mapping of nervous pathways are based partlyon the study of retrograde processes in the perikaryon, partlyon the demonstration of degenerative processes along the peripheral part of a transected axon. For this purpose, the Mar
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Herausgegeben von A. Brodal, Oslo . O. Elze, München· W. Hild, Galveston . R.Ortmann, Köln G. Töndury, Zürich· E. Wolft, Paris Schriftleitung G. Töndury, Zürich
Band 39 . Heft 1
lohn F. Alksne, Theodor W. Blackstad, Fred Walberg and Lowell E. White jr.
Electron Microscopy of Axon Degeneration: A ValuableTool in Experimental Neuroanatomy
W ith 20 Figures
Springer-Verlag Berlin Heidelberg GmbH 1966
Dozent Dr. Theodor W. Blackstad, Prof. Dr. Fred Walberg, Anatomisk Institutt, Universitetet i Oslo, Oslo 1JNorge, Karl Johans gate 47 (Domus Media) Dr. John F. Alksne, Harbor General Hospital, 1000 W. Carson Btreet, TorranceJCalif. 90509, U BA Dr. Lowell E. White jr., The Medical School, University of Washington, Beattle 5, W ash.JU BA
Supported by Grants NB-02215 and NB-02896 from the National Institute of Neurological Diseases and Blindness, U. S. Public Health Service. This aid is gratefully acknowledged. For technical assistance the authors are indebted to Mrs. J. Line Vaaland, Mr. B. V. Johansen and Mr. E. Risnes
ISBN 978-3-540-03493-3
ISBN 978-3-662-30450-1 (eBook)
DOI 10.1007/978-3-662-30450-1
Alle Rechte, insbesondere das der Übersetzung in fremde Sprachen, vorbehalten. Ohne ausdrückliche Genehmigung des Verlages ist es auch nicht gestattet, dieses Buch oder Teile daraus auf photomechanischem Wege (Photokopie, Mikrokopie) oder auf andere Art zu vervielfältigen
© by Springer-Verlag BerlinHeidelberg 1966. Library of Congress Catalog Card Number 64-20582 Originally published by Springer-Verlag Berlin Heidelberg New York in 1966. Titel-Nr. 4453. Die Wiedergabe von Gebrauchsnamen, Handelsnamen, Warenbezeichnungen nsw. in diesem Werk berechtigt auch ohne besondere Kennzeichnung nicht zu der Annahme, daß solche Namen im Sinn der Warenzeichenund Markenschutz-Gesetzgebung als frei zu betrachten wären und daher von jedermann benutzt werden dürften
Contents Page
1. Introduction . . . .
6
II. Material and methods
7
III. Observations and comments
13
l. The hippocampal region. a) Molecular layer of area dentata b) Layer II of presubiculum . . . c) Molecular layer of subiculum and hippocampus d) Pyramidal and adjacent layers in hippocampus (regio superior)
14 14 16 16
2. The brain stem. . . . . a) The inferior olive . . b) Dorsal column nuclei .
20 20
IV. Discussion . . . . . . . . a) Survival time b) Appearance of degeneration. c) Relation to silver impregnation V. Summary
19
23 25 25 27 28
29
Bibliography
29
Index . . .
32
I. Introduction Experimental methods for the mapping of nervous pathways are based partlyon the study of retrograde processes in the perikaryon, partlyon the demonstration of degenerative processes along the peripheral part of a transected axon. For this purpose, the Marchi method by which a selective staining of degenerating myelin is obtained has been extensively used. However, when this method is used the non-myelinated terminals of the transected axons are not stained. The introduction, about two decades ago, of silver impregnation as a means of tracing degenerating axo
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