Emergency Biosafety Management Practice in Laboratory of Shelter Hospital

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40(5):1-4,2020

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Emergency Biosafety Management Practice in Laboratory of Shelter Hospital Yu-song LIU1, Duan-liang PENG1, Jia YANG2, Dun-yan CHEN3, Hong-bing JIA4, Si-yuan YU5, Huan-huan CHEN6, Kang CHEN2, Lyu-rong LIU1# 1 Sichuan National Emergency Medical Rescue Team/Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital (East), Chengdu 610100, China 2 Sichuan National Emergency Medical Rescue Team/Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, Chengdu 610054, China 3 Fujian Provincial Hospital, Fuzhou 350001, China 4 China-Japan Friendship Hospital, Beijing 100029, China 5 Shanghai East Hospital, Shanghai 200120, China 6 Jiangsu Province Hospital/the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Huazhong University of Science and Technology 2020

Summary: At the end of 2019, the novel coronavirus infection outbroke in Wuhan, Hubei Province. On Feb. 2, 2020, Wuhan, as the worst-hit region, began to build “shelter hospital” rapidly to treat patients with mild illness. The shelter hospital has multiple functions such as emergency treatment, surgical treatment and clinical test, which can adapt to emergency medical rescue tasks. Based on the characteristics that shelter hospital only treats patients with mild illness, tests of shelter laboratory, including coronavirus nucleic acid detection, IgM/IgG antibody serology detection, monitoring and auxiliary diagnosis and/or a required blood routine, urine routine, C-reactive protein, calcitonin original, biochemical indicators (liver enzymes, myocardial enzymes, renal function, etc.) and blood coagulation function test etc, were used to provide important basis for the diagnosis and treatment of the disease. In order to ensure laboratory biosafety, it is necessary to first evaluate the harm level of various specimens. In the laboratory biosafety management, the harm level assessment of microorganisms is the core work of biosafety, which is of great significance to guarantee biosafety. As an emergency deployment affected by the environment, shelter laboratory must possess strong mobility. This paper will explore how to combine the biosafety model of traditional laboratory with the particularity of shelter laboratory to carry out effective work in response to the current epidemic. Key words: COVID-19; shelter laboratory; biosafety protection; specimen processing

On 11th February, 2019, the World Health Organization (WHO) officially named various diseases caused by novel coronavirus pneumonia (NCP) as corona virus disease, simplified as COVID-19[1, 2], and this disease quickly spread to the overseas areas[3], which poses a huge threat to the public health security. As the worst-hit region, the number of confirmed cases in Wuhan continued to increase. In order to solve this problem, our country began to construct shelter hospital. In order to strengthen the health emergency rescue and the prevention and control of COVID-19, shelter laboratories are guided to carry out tests related to novel co