Endocrine Disruptors and Puberty
Endocrine disruption represents one of the most controversial environmental issues of our time. Mounting evidence stemming from more than 10 years of experimental, epidemiological and clinical studies has transformed the once generally discounted subject
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Series Editor: P. Michael Conn, PhD Oregon Health & Science University Beaverton, OR, USA
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Evanthia Diamanti-Kandarakis
●
Andrea C. Gore
Editors
Endocrine Disruptors and Puberty
Editors Evanthia Diamanti-Kandarakis M.D., Ph.D. Third Department of Medicine Sotiria Hospital Medical School University of Athens Athens, 14578, Greece [email protected]
Andrea C. Gore Ph.D. Gustavus and Louise Pfeiffer Professor Pharmacology & Toxicology College of Pharmacy University of Texas at Austin Austin, TX 78712, USA [email protected]
ISBN 978-1-60761-560-6 e-ISBN 978-1-60761-561-3 DOI 10.1007/978-1-60761-561-3 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011941610 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
To Artemis, Eleni, Stelios and Anna, who keep teaching me that love is above all! To my parents for their inspiration and support and to all my patients who trust in my care. EDK To David, Rachel, Sarah and Isaac with all my love ACG
Preface
As the births of living creatures are ill-shapen, so are all innovations, which are the births of time. Sir Francis Bacon (On Innovation, ‘ Essays: 1597)
Mounting evidence stemming from over 10 years of experimental , epidemiological, as well as clinical studies has transformed the once generally discounted subject of endocrine disruptors into, currently, an issue of great concern, not only within the scientific community but among society as a whole. Thus, from initially constituting the domain of purely experimental basic research, it has now emerged as a major medical challenge. Today, it is one of especial pertinence to health specialists in light of the increasing confirmation of environmental endocrine disruption in humans. Equally significantly, it has been established that age at expos
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