Epidemiological features of primary glomerular disease in Turkey: a multicenter study by the Turkish Society of Nephrolo
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RESEARCH ARTICLE
Open Access
Epidemiological features of primary glomerular disease in Turkey: a multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group Aydin Turkmen1, Abdullah Sumnu2* , Egemen Cebeci3, Halil Yazici1, Necmi Eren4, Nurhan Seyahi5, Kamil Dilek6, Fatih Dede7, Ulver Derici8, Abdulkadir Unsal9, Garip Sahin10, Murat Sipahioglu11, Mahmut Gok12, Erhan Tatar13, Belda Dursun14, Savas Sipahi15, Murvet Yilmaz16, Gultekin Suleymanlar17, Sena Ulu18, Ozkan Gungor19, Sim Kutlay20, Zerrin Bicik Bahcebasi21, Idris Sahin22, Ilhan Kurultak23, Kultigin Turkmen24, Zulfikar Yilmaz25, Rumeyza Turan Kazancioglu26, Caner Cavdar27, Ferhan Candan28, Zeki Aydin29, Duriye Deren Oygar30, Cuma Bulent Gul31, Mustafa Arici32, Saime Paydas33, Dilek Guven Taymez34, Mehmet Kucuk35, Sinan Trablus36, Kenan Turgutalp37, Leyla Koc38, Siren Sezer39, Murat Duranay40, Simge Bardak41, Lutfullah Altintepe42, Izzet Hakki Arikan43, Alper Azak44, Ali Riza Odabas45, Gulizar Manga Sahin12 and Savas Ozturk3
Abstract Background: The largest data on the epidemiology of primary glomerular diseases (PGDs) are obtained from the databases of countries or centers. Here, we present the extended results of the Primary Glomerular Diseases Study of the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group. Methods: Data of patients who underwent renal biopsy and received the diagnosis of PGD were recorded in the database prepared for the study. A total of 4399 patients from 47 centers were evaluated between May 2009 and May 2019. The data obtained at the time of kidney biopsy were analyzed. After the exclusion of patients without light microscopy and immunofluorescence microscopy findings, a total of 3875 patients were included in the study. Results: The mean age was 41.5 ± 14.9 years. 1690 patients were female (43.6%) and 2185 (56.3%) were male. Nephrotic syndrome was the most common biopsy indication (51.7%). This was followed by asymptomatic urinary abnormalities (18.3%) and nephritic syndrome (17.8%). The most common PGD was IgA nephropathy (25.7%) followed by membranous nephropathy (25.6%) and focal segmental glomerulosclerosis (21.9%). The mean total number of glomeruli per biopsy was 17 ± 10. The mean baseline systolic blood pressure was 130 ± 20 mmHg and diastolic blood pressure was 81 ± 12 mmHg. The median proteinuria, serum creatinine, estimated GFR, and mean albumin values were 3300 (IQR: 1467–6307) mg/day, 1.0 (IQR: 0.7–1.6) mg/dL, 82.9 (IQR: 47.0–113.0) mL/min and (Continued on next page)
* Correspondence: [email protected] 2 Medical Faculty, Nephrology, Istanbul Medipol University, Istanbul, Turkey Full list of author information is available at the end of the article
© The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to th
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