Epigenetic Aspects of Chronic Diseases
Epigenetic Aspects of Chronic Diseases assembles in comprehensive form what is known about the role of epigenetics in chronic disease development. This book provides new insights into treatment, including modulation of epigenetic regulation. Each chapter
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Helmtrud I. Roach† • Felix Bronner Richard O.C. Oreffo (Editors)
Epigenetic Aspects of Chronic Diseases
Editors
Helmtrud I. Roach†, BA, MSc, PhD Bone and Joint Research Group Institute of Developmental Sciences School of Medicine University of Southampton Hampshire UK
Felix Bronner, PhD, Dr (h.c.) Department of Reconstructive Sciences The University of Connecticut Health Center Farmington, CT USA
Richard O.C. Oreffo, BSc, DPhil Bone and Joint Research Group Institute of Developmental Sciences School of Medicine University of Southampton Hampshire UK
ISBN 978-1-84882-643-4 e-ISBN 978-1-84882-644-1 DOI 10.1007/978-1-84882-644-1 A catalogue record for this book is available from the British Library Library of Congress Control Number: 2011921946 © Springer-Verlag London Limited 2011 Whilst we have made considerable efforts to contact all holders of copyright material contained in this book, we may have failed to locate some of them. Should holders wish to contact the Publisher, we will be happy to come to some arrangement with them. Apart from any fair dealing for the purposes of research or private study, or criticism or review, as permitted under the Copyright, Designs and Patents Act 1988, this publication may only be reproduced, stored or transmitted, in any form or by any means, with the prior permission in writing of the publishers, or in the case of reprographic reproduction in accordance with the terms of licences issued by the Copyright Licensing Agency. Enquiries concerning reproduction outside those terms should be sent to the publishers. The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore free for general use. Product liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. Printed on acid-free paper Springer Science+Business Media (www.springer.com)
This book is dedicated to Trudy Roach, who initiated and developed this treatise. Shortly after formulating the outline, Trudy was diagnosed with bowel cancer. For over a year Trudy responded to treatment and continued her research, teaching, and editorial activities. In her last few months, even though treatment was no longer effective, Trudy remained optimistic, a source of inspiration, and gained pleasure from her varied scholarly activities and time with her family. In the name of Trudy, we also dedicate this book to the many victims of the diseases discussed here, with the hope that in the not too distant future effective treatment, based in part on epigenetic insights, will improve the quality of life of patients with these diseases. Felix Bronner and Richard Oreffo
Preface
Epigenetics refers to processes that alter gene expression without changes in DNA sequence. In development, for example,
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