Erlotinib

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Erlotinib Skin eruptions in an elderly patient: case report A man, aged about 77 years, began receiving erlotinib for non-small cell lung cancer at a dosage of 150 mg/day for 1 month, followed by 100 mg/day for 2 months. Following 2 months of treatment, he was referred with the development of an eczema-like skin eruption with intense pruritus, and diarrhoea. An examination revealed erythema and oedema with skin desquamation on his inguinal and gluteal folds, and fissured eczema on his hands. He had a slight erythema on his arms, trunk and thighs, and had erythema with telangiectasia on his face. He received oral hydroxyzine, topical corticosteroids and emollients. In about 15 days, his skin lesions had improved. Santoro F, et al. Cutaneous adverse effects during therapy with an epidermal growth factor receptor (EGFR) inhibitor. Journal of Dermatological Treatment 17: 801043294 160-161, No. 3, Jun 2006 - Italy

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Reactions 26 Aug 2006 No. 1116