Evaluation of effects of positive airway pressure treatment on retinal fiber thickness and visual pathways using optic c
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ORIGINAL PAPER
Evaluation of effects of positive airway pressure treatment on retinal fiber thickness and visual pathways using optic coherence tomography and visual evoked potentials in the patients with severe obstructive sleep apnea syndrome Melike Batum . Ays¸ ın Kısabay . Hu¨seyin Mayalı . Tug˘ba Go¨ktalay . Emin Kurt . Deniz Selc¸uki . Hikmet Yılmaz
Received: 30 November 2019 / Accepted: 13 May 2020 Ó Springer Nature B.V. 2020
Abstract Introduction Hypoxia during sleep in obstructive sleep apnea syndrome (OSAS) increases intracranial pressure, decreases cerebral perfusion pressure, and alters vascular supply to the optic nerve. Pattern visual evoked potential (pVEP) has revealed that it causes alterations in the optic nerve, and optic coherence tomography has shown that it causes alterations in the retinal and macular layers. Objectives To detect and compare possible alterations in macula and peripapillary retinal nerve fiber thickness (pRNFL) using OCT and in the optic nerve pathways using pVEP before and after positive airway pressure (PAP) in the patients with severe OSAS. Materials and methods Thirty patients who were diagnosed as having severe OSAS in the neurologysleep outpatient clinic and 30 healthy control subjects were included in the study. Ophthalmic examinations
M. Batum (&) A. Kısabay D. Selc¸uki H. Yılmaz Department of Neurology, Celal Bayar University, 45000 Manisa, Turkey e-mail: [email protected] A. Kısabay e-mail: [email protected] D. Selc¸uki e-mail: [email protected] H. Yılmaz e-mail: [email protected]
were performed prior to (month 0) and after (month 6) PAP treatment, and pVEP (peak time [PT] and amplitude) and OCT parameters (peripapillary retinal-macular layers) were compared. Results In the comparison between the severe OSAS (before treatment) and control groups, thinning was found in pRNFL (average, nasal, inferior) and in the macular layers (external and internal superior quadrants) (p \ 0.05). pVEP investigation revealed increased PT in P100 and N145 waves and decreased amplitude of N75–P100 waves.In the comparisons before and after PAP treatment, a decrease in PT of N75 and P100 waves and increase in N75–P100 amplitudes were found. In the pRNFL, significant thickening was found in the layers with thinning before treatment, whereas no significant thickening was found in macular layers, except for the fovea.
H. Mayalı E. Kurt Department of Ophthalmology, Celal Bayar University, 45000 Manisa, Turkey e-mail: [email protected] E. Kurt e-mail: [email protected] T. Go¨ktalay Department of Chest Diseases, Celal Bayar University, 45000 Manisa, Turkey e-mail: [email protected]
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Int Ophthalmol
Discussion It was shown that PAP treatment in patients with severe OSAS prevents hypoxia without causing alterations in intraocular pressure and thus reduces inflammation and causes thickening in the pRNFL and macular layers. Keywords Peripapillary retinal nerve fiber layer Macula Obstructive slee
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