Evaluation of retina nerve fiber layer, ganglion cell-inner plexiform layer and lamina cribrosa in clinically unilateral
- PDF / 231,085 Bytes
- 7 Pages / 547.087 x 737.008 pts Page_size
- 59 Downloads / 140 Views
(0123456789().,-volV) ( 01234567 89().,-volV)
ORIGINAL PAPER
Evaluation of retina nerve fiber layer, ganglion cell-inner plexiform layer and lamina cribrosa in clinically unilateral exfoliative glaucoma Atılım Armag˘an Demirtas¸
. Zeynep Duru . Necati Duru . Hakika Erdog˘an
Received: 5 December 2019 / Accepted: 25 May 2020 Ó Springer Nature B.V. 2020
Abstract Purpose To compare retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer (GCIPL), the lamina cribrosa depth (LCD) and thickness (LCT) in unilateral exfoliative glaucoma (EXG) patients with their fellow eyes without exfoliation and control eyes. Methods This cross-sectional prospective singlecenter study consisted of 64 eyes of 32 patients with unilateral EXG and 35 eyes of controls. All subjects were examined with spectral domain optical coherence tomography for the RNFL and GC-IPL measurements. The LCD and LCT measurements were also obtained. Results The RNFL measurements at all quadrants were statistically thinner in EXG eyes than those in their eyes without EXG and control eyes (p \ 0.001 for average, superior, temporal and inferior; p = 0.004 for nasal). The EXG group had deeper LCD than their
eyes without EXG and control eyes (p \ 0.001, for both). The fellow eyes of EXG group had also deeper LCD than control eyes, with no statistical significance (p = 0.058). The mean LCT was thinner in EXG eyes compared to those in the eyes without EXG and control eyes (p \ 0.001, for both). The eyes without EXG and control eyes had similar LCT (p = 0.293). Conclusions Recent developments in imaging technology give the clinician detailed structural information about optic nerve head and retina such as GC-IPL, LCD and LCT. In addition to follow-up of RNFL changes, these new parameters may be useful in recognizing progression in EXG patients. Keywords Exfoliative glaucoma Lamina cribrosa depth Ganglion cell complex Retina nerve fiber layer Lamina cribrosa thickness
Introduction A. A. Demirtas¸ (&) Health Sciences University, Tepecik Training and Research Hospital, Izmir, Turkey e-mail: [email protected] A. A. Demirtas¸ Z. Duru N. Duru Health Sciences University, Kayseri Training and Research Hospital, Kayseri, Turkey H. Erdog˘an Department of Ophthalmology, Maltepe University, Istanbul, Turkey
Exfoliation syndrome (EXS) is a systemic disease defined by excessive aggregation of abnormal whitish fibrillar substance in intraocular and extraocular structures secondary to aging [1]. The relationship between EXS and glaucoma is also well known [2, 3]. The pathogenesis leading to glaucomatous damage is most probably secondary to both high intraocular pressure (IOP) and diminished blood circulation in the
123
Int Ophthalmol
retina, optic nerve head and choroidal and retrobulbar vessels [4–6]. In addition to diurnal variable high IOP levels and abnormal blood circulation, the optic nerve head structure abnormalities were also suggested to be an important factor in exfoliative glaucoma (EXG) [7–10]. The lamina cribrosa in EXG patient
Data Loading...
