Comparison of Spectralis-OCT, GDxVCC and GDxECC in assessing retinal nerve fiber layer (RNFL) in glaucomatous patients
- PDF / 671,424 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 94 Downloads / 170 Views
GLAUCOMA
Comparison of Spectralis-OCT, GDxVCC and GDxECC in assessing retinal nerve fiber layer (RNFL) in glaucomatous patients Maurice Schallenberg & Dirk Dekowski & Stephan Kremmer & J. Michael Selbach & Klaus-Peter Steuhl
Received: 1 February 2012 / Revised: 31 October 2012 / Accepted: 20 November 2012 / Published online: 19 December 2012 # Springer-Verlag Berlin Heidelberg 2012
Abstract Background Glaucomatous optic neuropathy is characterized by a progressive loss of retinal ganglion cells (RGCs). The defects in the peripapillary retinal nerve fiber layer (RNFL) have been reported to be the earliest sign of glaucoma. We determined the agreement between RNFL thickness assessments from spectral-domain OCT (Spectarlis HRA+OCT; Heidelberg Engeneering, Heidelberg, Germany), scanning laser polarimetry (SLP) with variable cornea compensation (GDxVCC; Carl Zeiss Meditec, Dublin, CA, USA), and SLP with enhanced cornea compensation (GDxECC; Carl Zeiss Meditec, Dublin, CA, USA) in glaucomatous patients. Furthermore, we investigate the influence of typical scan score (TSS) on the results of GDx assessments. Methods The enrolled subjects were devided into different groups by modified HODAPP visual field criteria. The peripapillary RNFL thickness was assessed with the three devices . ANOVA test, Pearson and Spearman correlation coefficient, and Bland-Altman plots were used to analyse the RNFL thickness assessments.
M. Schallenberg (*) Augenklinik, HELIOS Klinikum Wuppertal, Heusnerstrasse 40, 42283 Wuppertal, Germany e-mail: [email protected] M. Schallenberg : D. Dekowski : S. Kremmer : J. M. Selbach : K.-P. Steuhl Department of Ophthalmology, University Hospital Essen, University Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany S. Kremmer : J. M. Selbach Augenklinik, Evangelische Kliniken Gelsenkirchen, Munckelstrasse 27, 45879 Gelsenkirchen, Germany
Results Ninety-two eyes from 92 glaucomatous subjects were analysed. These were divided into four groups: preperimetric glaucoma (n026), mild glaucoma (n018), moderate glaucoma (n021), and severe glaucoma (n027). For Spectralis-OCT, the average RNFL thickness (mean ± SD) was 99.25±26.31 μm, 80.52±16.63 μm, 71.59±21.15 μm, and 63.85±20.86 μm for preperimetric, mild, moderate, and severe glaucoma respectively. For GDxVCC, the corresponding assessments were 52.63± 8.18 μm, 52.95±10.20 μm, 46.77±10.62 μm, and 49.70± 13.34 μm. For GDxECC, the assessments were 49.35± 6.52 μm, 45.92±7.21 μm, 42.19±8.00 μm, and 39.53± 8.45 μm. All Spectralis-GDxVCC and Spectralis-GDxECC differences were statistically significant by ANOVA test. The differences between GDxVCC and GDxECC were statistically significant only for severe glaucoma. There was a highly significant correlation between Spectralis-OCT and GDxECC, as well as Spectralis-OCT and GDxVCC, in assessing the RNFL thickness. The best instrument agreement was found between GDxECC and Spectralis-OCT. The RNFL thickness assessed with Spectralis-OCT and GDxECC showed a better correlation to visual field defects
Data Loading...
