Evaluation of spirometry values in relation to beta-2-adrenergic receptor gene polymorphism
- PDF / 629,746 Bytes
- 6 Pages / 597.968 x 844.582 pts Page_size
- 55 Downloads / 159 Views
EUROPEAN JOURNAL OF MEDICAL RESEARCH
Eur J Med Res (2010) 15(Suppl. II): 135-140
135 © I. Holzapfel Publishers 2010
EVALUAtION OF SPIROMEtRy VALUES IN RELAtION tO B EtA -2- ADRENERgIC R ECEPtOR g ENE P OLyMORPHISM I. Poziomkowska-gesicka1, E. Dzieciolowska-Baran2, A. gawlikowska-Sroka2, D. Slowik-Zylka3, t. Sroczynski3 1Department
of Clinical Allergology, 2 Department of general and Clinical Anatomy, 3 Department of Physiology, Pomeranian Medical University, Szczecin, Poland
Abstract Introduction: the vagus nerve plays a special role in the control of respiratory system activity which represents the parasympathetic part of the autonomic nervous system. A small bronchial innervation by the sympathetic system also is observed, and there is a significant expression of adrenergic receptors, in particular β2 receptors, in the airways. the development of genetics and molecular biology allows for a detailed study which can clarify the essential elements in the pathogenesis of many types of lung disease, as well as the physiological phenomena - bronchial smooth muscle tone and their contractile mechanism. Material and methods: the study involved 148 healthy male volunteers aged 20-26. In all subjects, gene polymorphism at nucleotide position 46 and 79 of β2adrenergic receptor (β2-ADR) was assessed. According to the gene polymorphism data, we divided the whole examined population of males into 6 groups for further studies. Moreover, in all the subjects, we performed spirometry testing to verify their pulmonary functions. Results: the basic values of spirometry tests in all subjects were in the range of normal values. the frequency of different genotypes in the gene polymorphism of the β2-adrenergic receptor at nucleotide positions 46 and 79 were typical for the Caucasian population. Analysis of the output values of spirometry, conducted in the particular groups based on their genotype, showed significant inter-group differences in the selected spirometry tests. Conclusions: Our results may be useful in explaining the differences in the measured values of spirometric indices in healthy subjects in relation to the polymorphism of β2-ADR, and may also contribute to the verification of standards for spirometric indices for this selected group of young males in the Polish population. Key words: β2-adrenergic receptor, gene polymorphism, spirometry
INtRODUCtION the bronchial smooth muscle tonus is determined by the effect of the nervous system and endogenous signal substances (ligands) supplied via the bloodstream,
as well as locally secreted substances [22]. Neural regulation is effected with the mediation of parasympathetic fibres in the autonomic nervous system innervating bronchia and one of its parts, defined as the nonadrenergic and noncholinergic system (NANC). Bronchial tonus is maintained by the neurons of the vagus nerve nuclei, whose excitability is modified by impulses received from the respiratory complex in the brain stem. Surprisingly, a very slight bronchial innervation by the sympathetic system is observed
Data Loading...
