Evaluation of the prescribing of proton pump inhibitors as stress ulcer prophylaxis for non-ICU patients in a Malaysian
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ORIGINAL RESEARCH ARTICLE
Evaluation of the prescribing of proton pump inhibitors as stress ulcer prophylaxis for non‑ICU patients in a Malaysian tertiary hospital Muhammad Eid Akkawi1,2 · Mohamed Hassan Elnaem1,2
© Springer Nature Switzerland AG 2020
Abstract Background Proton pump inhibitors (PPIs) are widely prescribed in hospital settings. Several reports have highlighted concerns about the inappropriate use of PPIs as stress ulcer prophylaxis (SUP) in patients outside the intensive care unit (ICU) setting. Little is known about this phenomenon in Malaysian hospitals. Aims and objectives This study aimed to evaluate the appropriateness of PPI prescribing as SUP for patients admitted to the general medical wards of a Malaysian tertiary hospital and to determine the rate of unnecessary prescription of PPI for discharged patients. Methods This was a retrospective cross-sectional study conducted in a tertiary hospital in Pahang, Malaysia. We reviewed the information held on electronic databases for patients admitted to the general medical wards from January to September 2019. Appropriateness of PPI prescribing was assessed using the criteria for SUP from predefined clinical guidelines. Results Of 660 screened patients admitted to the general medical wards, 200 were prescribed PPIs as SUP. Oral pantoprazole was the most frequently prescribed PPI (51.5%). Only 61 (30.5%) PPIs were prescribed according to current recommendations for the use of PPI for SUP. Sex, age, number of medications, length of hospital stay, and receiving PPI at discharge were not significantly associated with appropriateness of PPI prescribing. Half of the patients continued receiving PPIs at discharge without a documented indication. Conclusion Our findings indicated a high prevalence of inappropriate prescribing of PPIs as SUP for non-ICU patients. Interventions to reduce the unnecessary use of PPIs in Malaysian hospital settings are desperately required. The need for national criteria that address the proper indications and dosing regimens for PPIs as SUP in ICU and non-ICU patients is high.
Introduction Stress ulcer (SU) is a common acute condition characterized by erosive inflammation of the upper gastrointestinal tract that leads to mucosal damage. The intensity of the damage ranges from asymptomatic superficial lesions to significant upper gastrointestinal bleeding (UGIB) [1]. Injury to the gastrointestinal mucosal lining occurs because of mucosal ischemia, which impairs the protective mechanism * Muhammad Eid Akkawi [email protected]; [email protected] 1
Department of Pharmacy Practice, Faculty of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia
Quality Use of Medicines Research Group, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan, Malaysia
2
responsible for maintaining a healthy gastrointestinal mucosa [2]. SU is commonly encountered in patients who undergo treatment in the intensive care unit (ICU) [3]
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