Evaluation of three-dimensional silver-doped borate bioactive glass scaffolds for bone repair: Biodegradability, biocomp
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Shichang Zhaoc) Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
Xu Cui, Yangyi Pan, Wenhai Huang, and Song Ye School of Materials Science and Engineering, Tongji University, Shanghai 200092, China
Shihua Luo Department of Orthopaedic Surgery, Shanghai Jiaotong University Affiliated Ruijing Hospital, Shanghai 200233, China
Mohamed N. Rahaman Department of Materials Science and Engineering, and Center for Biomedical Science and Engineering, Missouri University of Science and Technology, Rolla, Missouri 65409, USA
Changqing Zhangb) Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
Deping Wanga) School of Materials Science and Engineering, Tongji University, Shanghai 200092, China (Received 3 January 2015; accepted 28 July 2015)
The development of synthetic scaffolds with a desirable combination of properties, such as bioactivity, the ability to locally deliver antibacterial agents and high osteogenic capacity, is a challenging but promising approach in bone tissue engineering. In this study, scaffolds of a borosilicate bioactive glass (composition: 6Na2O, 8K2O, 8MgO, 22CaO, 36B2O3, 18SiO2, 2P2O5; mol%) with controllable antibacterial activity were developed by doping the parent glass with varying amounts of Ag2O (0.05, 0.5, and 1.0 wt%). The addition of the Ag2O lowered the compressive strength and degradation of the bioactive glass scaffolds but it did not affect the formation of hydroxyapatite on the surface of the glass as determined by energy dispersive x-ray analysis, x-ray diffraction, and Fourier transform infrared analysis. The Ag2O-doped scaffolds showed a sustained release of Ag ions over more than 8 weeks in simulated body fluid and resistance against colonization by the bacterial strains Escherichia coli and Staphylococcus aureus. In vitro cell culture showed better adhesion, proliferation, and alkaline phosphatase activity of murine osteoblastic MC3T3-E1 cells on the Ag2O-doped bioactive glass scaffolds than on the undoped scaffolds. The results indicate that these Ag-doped borosilicate bioactive glass scaffolds may have potential in repairing bone coupled with providing a lower risk of bacterial infection.
Contributing Editor: Himanshu Jain Address all correspondence to these authors. a) e-mail: [email protected] b) e-mail: [email protected] c) These authors contributed equally to this work. DOI: 10.1557/jmr.2015.243
1–2.5% for primary implants2 and are even higher for revision surgeries.3 Infected implants can represent a severe threat to the patient’s health and provide a significant economic burden to the healthcare system. Clinically, bone defects can be reconstructed through the use of various bone grafts. However, current treatments based on the use of autologous bone grafts and allografts suffer from several limitations. Consequently, there is a growing interest in the development of synthetic bone grafts.4,5 Bioactive glasses undergo spec
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