Exercise intervention for post-treatment colorectal cancer survivors: a systematic review and meta-analysis
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REVIEW
Exercise intervention for post-treatment colorectal cancer survivors: a systematic review and meta-analysis Ruitong Gao 1 Lirong Guo 1
&
Tianzhuo Yu 1
&
Lu Liu 1
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Jiasi Bi 2
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Huiying Zhao 3
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Yujia Tao 4
&
Feng Li 1
&
Received: 28 March 2020 / Accepted: 29 May 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose This study aimed to explore the effects of exercise on post-treatment colorectal cancer survivors through a systematic review and meta-analysis as the current information is limited and controversial. Methods We searched PubMed, Web of Science, Embase, and Cochrane Library databases for randomized controlled trials that focused on exercise intervention for adult colorectal cancer survivors who had completed primary cancer treatment. We extracted and pooled information regarding psychosocial outcomes, physical functions, body composition, metabolic growth factors, and/ or tumor-related biomarkers. All data were assessed by two independent reviewers. The risk of bias was assessed using the Cochrane Collaboration’s tool. Results A total of 20 studies, which presented data from 1223 post-treatment colorectal cancer survivors, matched the inclusion criteria. Compared with usual care or usual lifestyle, exercise intervention increased VO2peak (n = 107, SMD = 0.72, 95% CI = 0.32 to 1.11, I2 = 41%, P = 0.0004), reduced fasting insulin levels and insulin resistance (n = 150, SMD = − 0.55, 95% CI = − 0.88 to − 0.23, I2 = 0%, P = 0.0009; SMD = − 0.62, 95% CI = − 0.95 to − 0.29, I2 = 0%, P = 0.0002), and decreased levels of sICAM1. Moderate-intensity exercise was associated with a more pro-inflammatory immune state, resulting in increased oxidative DNA damage. However, no evidence was found for effects of exercise on psychosocial outcomes or body composition. Conclusions Our results revealed that exercise could be a feasible and effective option for improving cardiopulmonary fitness, metabolism, and tumor-related biomarkers in post-treatment colorectal cancer survivors. Implications for Cancer Survivors Given the benefits of exercise for colorectal cancer survivors, they should be encouraged to become more physically active. Keywords Colorectal cancer survivors . Exercise . Post-treatment . Systematic review
Feng Li and Lirong Guo contributed equally to this work. * Feng Li [email protected]
Huiying Zhao [email protected]
* Lirong Guo [email protected]
Yujia Tao [email protected]
Ruitong Gao [email protected] Tianzhuo Yu [email protected]
1
School of Nursing, Jilin University, 965 Xinjiang Street, Changchun, Jilin 130000, China
2
Nursing Department, the First Bethune Hospital of Jilin University, Changchun, Jilin 130021, China
3
Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, China
4
School of Physical Education and Sport Training, Shanghai University of Sport, 650 Qingyuanhuan Road, Yangpu District, Shanghai 200082, China
Lu Liu [email protected]
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