Patient-reported outcomes of non-pharmacological interventions for endometrial cancer survivors: a systematic review
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REVIEW
Patient-reported outcomes of non-pharmacological interventions for endometrial cancer survivors: a systematic review Ashley Buchanan 1 & McKenzie Roddy 2 & Hoda Badr 1 Received: 31 July 2020 / Accepted: 18 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose The objective of this review was to assess the efficacy of non-pharmacological interventions on endometrial cancer (EC) survivors’ QOL, and their use of patient-reported outcome measures (PROMs). Methods We conducted a systematic review of randomized controlled trials (RCTs) of non-pharmacological interventions that assessed the impact of intervention on EC survivors’ general and domain-specific QOL (i.e., physical, psychological, and social well-being) using PROMs. Results Of the 3178 studies identified, 28 full-text articles were reviewed, and 10 were included in the review. Nine RCTs assessed at least one PROM as a primary outcome and six assessed a PROM as a secondary outcome, but few studies used validated PROMs. Significant improvements in general QOL were found in two studies, domain-specific QOL in three studies, and both general and domain-specific QOL in three studies; however, effect sizes ranged from small to large and no significant effects were found for social well-being and few were found for psychological well-being. Conclusions Few non-pharmacological interventions for EC survivors targeted QOL, even though QOL was assessed as either a primary or secondary outcome of the RCT. Despite this, findings suggest that non-pharmacological interventions for EC survivors hold promise for improving general and domain-specific QOL. Use of validated PROMs would greatly enhance outcome reporting and facilitate comparisons across studies. More interventions are also needed that address social and psychological functioning in this population. Implications for Cancer Survivors Our review highlights a need to (1) expand non-pharmacological RCTs for EC survivors, (2) increase the use of validated PROMs measuring QOL, and (3) address psychosocial domains of QOL when developing interventions for this population. Keywords Endometrial cancer survivors . Quality of life . Well-being . Lifestyle interventions . Behavioral interventions . Patient reported outcomes
Introduction Women with endometrial cancer (EC) are the second largest population of female cancer survivors in the USA [1, 2]. It is Supplementary Information The online version of this article (https:// doi.org/10.1007/s11764-020-00946-z) contains supplementary material, which is available to authorized users. * Hoda Badr [email protected] 1
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
2
Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
estimated that 81% will live 5 years or more after diagnosis [3] thanks to treatment advances and the fact that most EC tumors are well-differentiated and localized [1, 4]. However, EC survivors have poorer quality of life (QOL) relativ
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