Expression and Clinical Significance of Wnt Players and Survivin in Pituitary Tumours
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Expression and Clinical Significance of Wnt Players and Survivin in Pituitary Tumours Robert Formosa & Mark Gruppetta & Sharon Falzon & Graziella Santillo & James DeGaetano & Angela Xuereb-Anastasi & Josanne Vassallo
Published online: 12 February 2012 # Springer Science+Business Media, LLC 2012
Abstract Deregulation of the Wnt pathway has been implicated in oncogenesis of numerous tissues including the pituitary gland. Immunohistochemical localization and quantification of β-catenin, Cyclin D1, c-MYC and Survivin expression in 47 pituitary adenomas (35 non-functioning, seven GH-secreting, three prolactinomas, two ACTHsecreting tumour) and six normal controls was undertaken in this study and correlation of protein expression to patient and tumour characteristics analysed. β-catenin was strictly membrane-bound with no difference observed between normal and tumour tissue. In contrast, Cyclin D1 and c-MYC localization was nuclear and significantly higher in tumour versus normal tissue (p
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