Expression of the Serrated Markers Annexin A10 or Gremlin1 in Colonic Adenocarcinomas: Morphology and Prognostic Values
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ORIGINAL ARTICLE
Expression of the Serrated Markers Annexin A10 or Gremlin1 in Colonic Adenocarcinomas: Morphology and Prognostic Values Benjamin Marquet 1,2 & Aude Marchal Bressenot 1,2 & Caroline Fichel 2 & Nicole Bouland 2 & Coralie Barbe 3 & Olivier Bouché 4 & Reza Kianmanesh 5 & Marie-Danièle Diebold 1,2 & Camille Boulagnon-Rombi 1,2,6 Received: 13 November 2019 / Accepted: 15 June 2020 # Arányi Lajos Foundation 2020
Abstract Describe clinical, histological and molecular charatcteristics and prognosis values of the serrated candidate markers AnnexinA10 and Gremlin1 in colon adenocarcinomas. Immunohistochemical expression of AnnexinA10 and Gremlin1 was evaluated on 346 colonic adenocarcinomas. Clinicopathological, molecular features and prognostic characteristics were then evaluated. A total of 40 colonic adenocarcinomas expressed AnnexinA10 (11.6%) and, 115 expressed Gremlin1 (40.4%). AnnexinA10 expression was significantly associated, on univariate analyses, with female gender (p = 0.03), right tumor location (p < 0.001), differentiation grade 3 (p < 0.001), serrated adenocarcinoma subtype (p < 0.001), serrated (p < 0.001), medullary (p = 0.005), and mucinous component (p = 0.004), cytoplasmic eosinophilia (p < 0.001), discernible nuclei (p = 0.001), preserved polarity (p < 0.001), lymphatic invasion (p = 0.01), BRAFV600E mutation (p < 0.001), MSI-H status (p < 0.001) and CIMP-H status (p = 0.019). Multivariate analyses revealed that mucinous component (p = 0.002), lymphatic invasion (p = 0.02) and BRAFV600E mutation (p < 0.001) were independently associated with AnnexinA10 expression. In addition, AnnexinA10 was an indicator of poorer overall survival (OS) in UICC stage IV adenocarcinomas (p = 0.01) only. Gremlin1 expression was neither associated with serrated adenocarcinoma subtype (p = 0.51) nor with AnnexinA10 expression (p = 0,31), but was significantly associated, in univariate analysis with male gender (p = 0.002), younger age (p = 0.002), left tumor location (p = 0.04), and MSS status (p = 0.03). Gremlin1 expression was associated with better OS only in UICC stage III colon adenocarcinomas (p = 0.006). Colon adenocarcinomas expressing AnnexinA10 have distinct clinico-pathological and molecular features. AnnexinA10 expression is an indicator of poorer OS in UICC stage IV patients. Gremlin1 expression is not associated with serrated adenocarcinomas subtype. Its expression was associated with better OS in UICC Stage III patients. Keywords Colorectal neoplasms . AnnexinA10 . Gremlin1 . Prognosis . Serrated adenocarcinoma
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12253-020-00857-5) contains supplementary material, which is available to authorized users. * Benjamin Marquet [email protected] 1
Department of Biopathology, Academic Hospital, rue du Général Koenig, 51100 Reims, France
2
Department of Pathology, Medicine University, Reims, France
3
Clinical Research Unit, Academic Hospital, Reims, France
4
Gatroenterology and Digestive Oncol
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