Extracellular Matrix in Tumor Biology
This volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover
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Rolf A. Brekken Dwayne Stupack Editors
Extracellular Matrix in Tumor Biology
Biology of Extracellular Matrix
More information about this series at http://www.springer.com/series/8422
Rolf A. Brekken • Dwayne Stupack Editors
Extracellular Matrix in Tumor Biology
Editors Rolf A. Brekken Hamon Center for Therapeutic Oncology Research UT Southwestern Medical Center Dallas, Texas USA
Dwayne Stupack Department of Reproductive Medicine University of California La Jolla, California USA
ISSN 0887-3224 ISSN 2191-1959 (electronic) Biology of Extracellular Matrix ISBN 978-3-319-60906-5 ISBN 978-3-319-60907-2 (eBook) DOI 10.1007/978-3-319-60907-2 Library of Congress Control Number: 2017948241 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
One of the first “mantras” encountered by non-matrix biologists, as they enter the field of matrix biology, is that the extracellular matrix (ECM) is not simply the glue that holds tissues together. To many matrix biologists, this notion is self-evident; after all, biologists have understood for more than eight decades that there is a unique molecular complexity to the ECM and, moreover, have known that different histological tissues exhibit different ECM components. The concept that the complexities and variances in ECM deposition are critical to the unique mechanical and adhesive structures of a given tissue is appreciated and validates the current collection of chapters focused on the contribution of the ECM to cancer biology. Why should it be a surprise that the ECM would be critical to guide, inform, sustain, and signal under essentially every physio
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