The Extracellular Matrix Methods and Protocols
This volume details established experimental protocols on the isolation, characterization, and detection of extracellular matrix (ECM) molecules as well as methods to study the activity and role of ECM components on various biological functions, the forma
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Davide Vigetti Achilleas D. Theocharis Editors
The Extracellular Matrix Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
The Extracellular Matrix Methods and Protocols
Edited by
Davide Vigetti Department of Medicine and Surgery, University of Insubria, Varese, Italy
Achilleas D. Theocharis Department of Chemistry, University of Patras, Patras, Greece
Editors Davide Vigetti Department of Medicine and Surgery University of Insubria Varese, Italy
Achilleas D. Theocharis Department of Chemistry University of Patras Patras, Greece
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-9132-7 ISBN 978-1-4939-9133-4 (eBook) https://doi.org/10.1007/978-1-4939-9133-4 Library of Congress Control Number: 2019932812 © Springer Science+Business Media, LLC, part of Springer Nature 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Extracellular matrix (ECM) is a three-dimensional noncellular network where cells reside. Apart from structural support, ECM controls cell phenotype and functions in tissues and organs. ECM components are composed of fibrillar proteins including collagens, fibronectin, laminins and elastin, proteoglycans, hyaluronan, and several glycoproteins including matricellular proteins. All these ECM molecules interact with each other as well as with certain cell surface receptors creating complex but well-organized networks. Specifically, the elements of the ECMs can influence tissue homeostasis, cell pro
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