Extrahepatic biliary tract visualization using near-infrared fluorescence imaging with indocyanine green: optimization o
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and Other Interventional Techniques
Extrahepatic biliary tract visualization using near‑infrared fluorescence imaging with indocyanine green: optimization of dose and dosing time Qiangxing Chen1 · Rou Zhou2 · Jiefeng Weng1 · Yueyuan Lai1 · Hui Liu1 · Jiao Kuang1 · Shuai Zhang1 · Zhaofeng Wu1 · Wen Wang1 · Weili Gu1 Received: 21 December 2019 / Accepted: 29 September 2020 © The Author(s) 2020
Abstract Background The dose and dosing time of indocyanine green (ICG) vary among fluorescence cholangiography (FC) studies. The purpose of this prospective, randomized, exploratory clinical trial was to optimize the dose and dosing time of ICG. Methods PubMed was searched to determine the optimal dose. To optimize the dosing time of ICG, a clinical trial was designed with two parts. The first part included patients with T tubes for more than 1 month. After the patient was injected with ICG, bile was collected at 10 time points to explore the change and trends of bile fluorescence intensity (FI). In addition, the results of the first experiment were used to setup a randomized controlled trial (RCT) that aimed to find the optimal dosing timing for ICG injections for laparoscopic cholecystectomy (LC). During surgery, imaging data were collected for analysis. Results After performing a systematic review, the ICG injection dose for each patient in the clinical trial was 10 mg. Five patients were included in the first part of the study. Bile collected 8 h after ICG injection had a higher FI than bile collected at other time points (p
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