Extricating the Association Between the Prognostic Factors of Colorectal Cancer
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ORIGINAL RESEARCH
Extricating the Association Between the Prognostic Factors of Colorectal Cancer Younis Mohd 1 & Balamuralikrishnan Balasubramanian 2,3 & Arun Meyyazhagan 2,4 & Haripriya Kuchi Bhotla 2 & Suresh Kumar Shanmugam 2,5 & Mithun Kumar Ramesh Kumar 6 & Manikantan Pappusamy 4 & Karthick Kumar Alagamuthu 2,7 & Sasikala Keshavarao 2 & Vijaya Anand Arumugam 1 Accepted: 6 October 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose Colorectal cancer (CRC) is one of the recurring and lethal gastrointestinal tract disease rankings as the primary cause of worldwide morbidity and mortality. In general, the tumour node metastasis (TNM) and Dukes classification assist in diagnosis, prognosis and treatments of CRC along with haematological examinations and tumour demographic characterisations in patients. Methods The present investigation is carried out on clinically acknowledged sixty-five CRC patients based on haematological findings and are sorted into stages using TNM and Dukes. The present study is to find the association between haematological findings, demographic characters, differentiation position, lymph node invasion and tumour node metastasis in CRC patients in accordance with their age. Results We observed significant (p < 0.05) nexus between lymph node metastasis and tumour node metastasis on the basis of tumour’s differentiation demographic positioning and age of the individuals. Conclusion Earlier location tracing and medicinal treatment or surgery lessen the chance of CRC morbidity and mortality along with prolonging survival rate via prognostic factors and disease position determination. Keywords Colorectal cancer . Haematology . Lymph node metastasis . Staging
Introduction Colorectal cancer (CRC) is an omnipresent lethal melancholy linked to the bowl part of our body, the large intestine triggered by both genetic and environmental factors [1–3] with evident
notability for its incidence, morbidity and mortality rate around the globe. Internationally, CRC is ranked as the third most customarily diagnosed cancer in males and second in females. According to the World Health Organization (WHO) GLOBOCAN 2018 database, almost 1.8 million new cases are
Balamuralikrishnan Balasubramanian and Arun Meyyazhagan contributed equally to this work. Balamuralikrishnan Balasubramanian and Arun Meyyazhagan are equal contributors and are first authors. * Vijaya Anand Arumugam [email protected]
4
Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, Karnataka 560029, India
1
Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu 641046, India
5
Department of Animal Resource and Sciences, Dankook University, Cheonan, South Korea
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2
Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu 461046, India
Department of General Surgery, Mahatma Gandhi Medical College and Resear
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