Fabrication and evaluation of bamboo fabric coated with extracts of Curcuma longa , Centella asiatica and Azadirachta in
- PDF / 2,000,660 Bytes
- 13 Pages / 595.276 x 790.866 pts Page_size
- 56 Downloads / 220 Views
RESEARCH ARTICLE
Fabrication and evaluation of bamboo fabric coated with extracts of Curcuma longa, Centella asiatica and Azadirachta indica as a wound dressing material Sidhra Syed Zameer Ahmed1 · Naresh Balu1 · Syed Zameer Ahmed Khader1 · Mohamed Rafi Mahboob2 · Shanmugasundaram O. Lakshmanan3 · Manimaran Vetrivel1 Received: 10 December 2019 / Accepted: 4 September 2020 © Institute of Korean Medicine, Kyung Hee University 2020
Abstract Biomaterials are used on wounds as a dressing material to prevent the infection and to heal the wounds. In this present study, pure bamboo fabric has been selected for construction of functional part of bandage, coated with natural herbs such as Azadirachta indica, Centella asiatica, and Curcuma longa by microcapsules and exhaustion method. The binding of extracts to the fabric was confirmed through FTIR and FESEM analysis at 1 µm magnification. The air-permeability of the fabricate samples shows 100 cm3/cm2/s and the bursting strength was found to be 5.5 kg/cm2. The extension at break and recover of fabricated material was 101% and 24% respectively. The extract coated fabric expressed good water contact angle (50.51°–58.69°) and swelling property of about 337–320% at 10 mg/ml extract concentration. All fabrics exhibited good antibacterial activity against Staphylococcus aureus, Escherichia coli and Bacillus subtilis, the major microbes present in the wounds. The prepared dressing material had shown only 20% degradation against lysozyme enzyme with no allergic reactions. Furthermore, wound healing ability of BFC-Cl, BFC-Ai and BFC-Ca were tested on Albino Wistar rats and found that extracts coated fabric took 15 days for complete healing of wound.
* Syed Zameer Ahmed Khader [email protected] 1
Department of Biotechnology, K. S. Rangasamy College of Technology, K.S.R. Kalvinagar, Tiruchengode 637 215, Tamil Nadu, India
2
Department of Physics, C. Abdul Hakeem College, Melvisharam, Vellore, Tamil Nadu 632509, India
3
Department of Textile Technology, K. S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu, 637 215, India
13
Vol.:(0123456789)
S. Syed Zameer Ahmed et al.
Graphic abstract
Keywords Azadirachta indica · Centella asiatica · Curcuma longa · Bamboo fabric · Albino Wistar rats · Wound healing · Antimicrobial
Introduction Wounds are damages resulted from the physical injury that leads to opening or breaking of skin which includes cuts, scrapes, scratches, and punctured skin. Wound are likely to become chronic when there is a failure in the sequential phases of healing (Demidova et al. 2012). The human body
13
generally equipped with a self-healing defense mechanism, but under some critical conditions such as microbial infection, the wound healing process can be delayed. In some cases, the complexity of wound leads to lots of pain and cost in treatment (Prafulla et al. 2015). Wound dressing plays an important role in the healing if properly covered it reduces the time for healing and decrease the chances of scar
Fabrication and evalu
Data Loading...
