Hepatoprotective effect of Centella asiatica 50% ethanol extract against acetaminophen-induced acute liver injury in BAL
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eISSN 2234-2753 pISSN 1976-8257
Toxicol Res. https://doi.org/10.1007/s43188-020-00063-0
ORIGINAL ARTICLE
Hepatoprotective effect of Centella asiatica 50% ethanol extract against acetaminophen‑induced acute liver injury in BALB/c mice Dae Won Park1,2 · Hyelin Jeon2,3 · Jeong Eun Kwon1,2 · Young Geun Lee1 · Rina So1,2 · Tae Hwan Choe1,2 · Yong Joon Jeong3 · Se Chan Kang1,2 Received: 19 May 2020 / Revised: 12 August 2020 / Accepted: 21 August 2020 © Korean Society of Toxicology 2020
Abstract N-acetyl-p-aminophenol (acetaminophen, APAP) is a well-known component of analgesic and antipyretic monotherapy products. However, exceeding the recommended dose can lead to serious injury to the liver. We conducted this study to determine the potential of Centella asiatica as a natural substance to protect against APAP-induced liver injury. When acute hepatotoxicity was induced in mice by APAP overdose, their liver weight decreased significantly (p
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