Fabrication of Cylindrical Magnetic Nanoparticles for Functionalization of Polyelectrolyte Microcapsules
- PDF / 722,844 Bytes
- 7 Pages / 612 x 792 pts (letter) Page_size
- 29 Downloads / 240 Views
MATERIALS IN BIOLOGY AND MEDICINE
Fabrication of Cylindrical Magnetic Nanoparticles for Functionalization of Polyelectrolyte Microcapsules I. M. Doludenkoa,*, A. V. Mikheeva, b, I. A. Burmistrova, D. B. Trushinaa, c, T. N. Borodinaa, c, T. V. Bukreevaa, d, and D. L. Zagorskiia a Federal
Research Center Crystallography and Photonics, Russian Academy of Sciences, Moscow, 119333 Russia b Moscow State University, Moscow, 119991 Russia c Sechenov First Moscow State Medical University, Moscow, 119991 Russia d National Research Center Kurchatov Institute, Moscow, 123098 Russia *e-mail: [email protected] Received December 16, 2019; revised December 16, 2019; accepted February 17, 2020
Abstract—A problem of fabrication of magnetic polymer capsules for targeted drug delivery is considered. Magnetic nanoparticles are used in the problem under study. A method for fabrication of such particles involving synthesis of layered nanowires with alternating layers of the specified magnetic metal and sacrificial layers of nonmagnetic metal is proposed. A method for template-assisted synthesis based on ac-potential electroplating of specified metals in the pores of track membranes is used to fabricate wires with a diameter of 100 nm with nickel layers of 400 and 200 nm. A method for the subsequent extraction of nickel fragments using selective etching (removal) of copper fragments is developed. Procedures that prevent aggregation of magnetic nanoparticles and penetration of the nanoparticles in the shells of polymer capsules are considered. DOI: 10.1134/S1063784220090121
INTRODUCTION It is known that magnetic particles are widely employed in biology and medicine. Targeted drug delivery is among topical problems under study. For efficient treatment, a drug must be delivered to organism at a specified location and be activated therein. (Relatively high doses are needed when the organism is affected as a whole, and side effects are probable.) A method to solve such a problem can be based on encapsulation, which employs deposition of a drug to a capsule that is used for targeted delivery. The corresponding works were actively performed over the last 10–15 years. Successful applications of polymer multilayer capsules for drug delivery and procedure for controlled release can be found in [1]. Analysis of several methods for fabrication of capsules, delivery of drug molecules into the capsules and to the capsule shells, and possible methods for functionalization have been presented in [2]. Application of polyelectrolyte and nanocomposite microcapsules (fabricated with the aid of layer deposition) for encapsulation and drug delivery for diagnostic purposes has been reviewed in [3]. Several methods to improve the functional properties of capsules (e.g., ultrasound, external magnetic fields (MFs), and laser and short-wavelength irradiation) have been considered. It has been mentioned that
short-term ultrasonic or IR irradiation can be used for opening of capsules. A method for functionalization of capsules can be based on introduction of m
Data Loading...
