Fabrication of polysaccharides-based hydrogel films for transdermal sustained delivery of Ibuprofen
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ORIGINAL RESEARCH
Fabrication of polysaccharides-based hydrogel films for transdermal sustained delivery of Ibuprofen Xiao-Hui Wang . Ting Su . Jin Zhao . Zhi Wu . Dong Wang . Wen-Na Zhang . Qing-Xi Wu . Yan Chen
Received: 11 March 2020 / Accepted: 30 September 2020 Ó Springer Nature B.V. 2020
Abstract Water-soluble polysaccharides of cellulose sulfate (NaCS) and chitosan hydrochloride (CHC) were chosen as the brick materials, while sodium tripolyphosphate (STPP) as a special ‘‘cement’’, the NaCS/CHC/STPP hydrogel films loaded with Ibuprofen were fabricated via self-assembly method. The prepared hydrogel films were characterized via SEM, FTIR, TGA and XRD. It manifested that the hydrogel films formed a dense three-dimensional network with a regular shape, and NaCS, CHC and STPP were involved in the formation of polyelectrolyte complex via electrostatic interaction. The Ibuprofen-loaded
hydrogel films possessed respective loading and encapsulation efficiency of 43.15 ± 4.88% and 60.65 ± 4.68%. It verified that the hydrogel films had favourable sustained release profile during 1440 min test, in which Ibuprofen could penetrate through the skin of mouse in a transdermal drug delivery (TDD) model. The cytotoxicity assays indicated that the hydrogel films had non-toxicity and good biocompatibility. All these results shed light on the hydrogel films prepared could be used to design potential TDD vehicles.
X.-H. Wang T. Su J. Zhao Z. Wu D. Wang W.-N. Zhang Q.-X. Wu (&) Y. Chen School of Life Sciences, Anhui University, Jiulong Road 111, Hefei 230601, Anhui, China e-mail: [email protected] W.-N. Zhang Q.-X. Wu Y. Chen Anhui Key Laboratory of Modern Biomanufacturing, Hefei 230601, Anhui, China W.-N. Zhang Q.-X. Wu Y. Chen Key Laboratory of Eco-engineering and Biotechnology of Anhui Province, Hefei 230601, Anhui, China
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Graphic abstract
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Keywords Hydrogel film Cellulose sulfate Chitosan hydrochloride Transdermal delivery Sustained release
Introduction As an effective non-steroidal anti-inflammatory drug (NSAID), Ibuprofen is broadly applied in the treatment of pain, rheumatoid arthritis and other musculoskeletal problems (Rhee et al. 2008). Oral formulation is a normal type in designing Ibuprofen-loaded drug delivery systems (Javanbakht et al. 2018). However, the application of Ibuprofen is limited due to its low water-solubility, short biological half-life (0.5–2 h) and rapid clearance after oral ingestion (Paavola et al. 2016). In practice, patients need take the medicine frequently so as to maintain an effective blood concentration, which often results in serious side effects, e.g., gastric mucosal damage and overburden of kidney (Deng et al. 2018). Thus, it’s meaningful to develop novel and efficient Ibuprofen delivery systems with low adverse reactions (Abioye et al. 2015). Transdermal drug d
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