68 Ga-Labelled Carbon Nanoparticles for Ventilation PET/CT Imaging: Physical Properties Study and Comparison with Techne
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RESEARCH ARTICLE
68
Ga-Labelled Carbon Nanoparticles for Ventilation PET/CT Imaging: Physical Properties Study and Comparison with Technegas®
Frédérique Blanc-Béguin ,1 Philippe Eliès,2 Philippe Robin,1 Raphaël Tripier,3 Nelly Kervarec,2 Catherine A. Lemarié,4 Simon Hennebicq,1 Cécile Tromeur,5 Virginie Cogulet,6 Pierre-Yves Salaün,1 Pierre-Yves Le Roux1 1
Médecine Nucléaire, CHRU Brest, EA3878 (GETBO) IFR 148, Univ Brest, Avenue Foch, 29609, Brest Cedex, France Service Général des plateformes, Plateforme d’Imagerie et de Mesures en Microscopie, Université de Brest, Université Bretagne Loire, Avenue Le Gorgeu, 29200, Brest, France 3 Univ Brest UMR-CNRS 6521 (CEMCA), IFR 148, Avenue Le Gorgeu, 29200, Brest, France 4 Univ Brest, EA3878 (GETBO), INSERM 1078, Avenue Camille Desmoulins, 29200, Brest, France 5 Pneumologie, CHRU Brest, EA3878 (GETBO) IFR 148, Boulevard Tanguy Prigent, 29609, Brest Cedex, France 6 Pharmacie, CHRU Brest, Avenue Foch, 29609, Brest Cedex, France 2
Abstract Purpose: The use of 68Ga-labelled carbon nanoparticles has been proposed for lung ventilation PET/CT imaging. However, no study has assessed the physical properties of 68Ga-labelled carbon nanoparticles. The aim of this study therefore was to evaluate the shape and size of 68 Ga-labelled carbon nanoparticles, and to determine the composition of the aerosol, as opposed to 99mTc-labelled carbon nanoparticles aerosol. Procedures: 99mTc- and 68Ga-labelled carbon nanoparticles, stable gallium carbon nanoparticles, 0.9 % NaCl and 0.1 N HCl-based carbon nanoparticles were produced using an unmodified Technegas® generator, following the usual technique used for clinical Technegas® production. The shape and size of particles were studied by transmission electron microscopy (TEM) after decay of the radioactive samples. The composition of the 68Zn- and 99Tc-labelled carbon nanoparticles aerosols was assessed using scanning electron microscopy (SEM) coupled with energy dispersive X-ray (EDX) analysis after decay of the 68Ga- and 99mTc-labelled carbon nanoparticles, respectively. Results: On TEM, all samples showed similar shape with hexagonally structured primary particles, agglomerated in clusters. The mean diameters of primary stable gallium carbon nanoparticles, 99Tc- and 68Zn-labelled carbon nanoparticles were 22.4 ± 10 nm, 20.9 ± 7.2 nm and 19.8 ± 11.7 nm, respectively. Conclusion: Using Technegas® generator in the usual clinical way, 99mTc- and 68Ga-labelled carbon nanoparticles demonstrated similar shape and diameters in the same size range size.
Correspondence to: Frédérique Blanc-Béguin; e-mail: [email protected], Pierre-Yves Roux; e-mail: [email protected]
Blanc-Béguin F. et al.:
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Ga Aerosol for Ventilation PET Imaging
These results support the use of 68Ga-labelled carbon nanoparticles for the assessment of regional lung ventilation function with PET imaging. Key words: Carbon nanoparticles, Gallium-68, Physical properties, Ventilation PET/CT
Introduction Technegas® is a 99mTc-labelled aerosol which is a
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