Feasibility study for evaluating lumbar intervertebral disc degeneration using histogram analysis of T2* values
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ORIGINAL ARTICLE
Feasibility study for evaluating lumbar intervertebral disc degeneration using histogram analysis of T2* values Xiaoqing Liang1 · Ruyi Xie1 · Bowen Hou1 · Yitong Li1 · Yan Xiong1 · Cuilin Yin1 · Weiyin Vivian Liu2 · John Morelli3 · Xiaoming Li1 Received: 24 March 2020 / Revised: 16 May 2020 / Accepted: 24 May 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose To evaluate the feasibility of histogram analysis of T2* value for the detection and grading of degenerative lumbar intervertebral discs (IVDs) and for the characterization of microstructural heterogeneity of discs. Methods Two hundred fourteen lumbar IVDs of 44 subjects with chronic low back pain were examined using sagittal T2WI and axial T2* mapping. All IVDs were classified according to the Pfirrmann grade on T2WI. The correlations between histogram-derived parameters based on T2* values (T2*-HPs) of IVDs and Pfirrmann grade as well as between “red zone ratio” (area of “red zone” on T2* color maps over cross-sectional area of corresponding IVDs) and Pfirrmann grade were calculated. Results The agreement for Pfirrmann grade of IVDs was excellent (κ = 0.808, P 0.40, moderate agreement; 0.40 ≥ κ > 0.20, fair agreement; and κ 0.75 was considered to be excellent agreement. Spearman rank coefficient test was performed to compare the correlation between T2*-HPs and Pfirrmann grade, as well as the relationship between the “red zone ratio” and Pfirrmann grade (|r| ≥ 0.7, high correlation; 0.7 > |r| ≥ 0.4, moderate correlation; |r|
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