Intervertebral disc degeneration associated with vertebral marrow fat, assessed using quantitative magnetic resonance im
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SCIENTIFIC ARTICLE
Intervertebral disc degeneration associated with vertebral marrow fat, assessed using quantitative magnetic resonance imaging Yayun Ji 1 & Weifeng Hong 1 & Mouyuan Liu 1 & Yuying Liang 1 & YongYan Deng 1 & Liheng Ma 1 Received: 28 December 2019 / Revised: 10 March 2020 / Accepted: 10 March 2020 # The Author(s) 2020
Abstract Objective To investigate the potential clinical application of quantitative MRI in assessing the correlation between lumbar vertebrae bone marrow fat deposition and intervertebral disc degeneration. Materials and methods A total of 104 chronic lower-back pain volunteers underwent 3.0-T MRI with T2-weighted imaging, T2 mapping, and iterative decomposition of water and fat with echo asymmetry and least squares estimation (IDEAL-IQ) between August 2018 and June 2019. Each disc was assessed with T2 value by T2 mapping, and the L1-S1 vertebral bone marrow fat fraction was assessed by IDEAL-IQ. The differences and relationship between T2 value and the adjacent vertebral bone marrow fat fraction values within the five Pfirrmann groups, five age groups, and five lumbar levels were statistically analyzed. Results The vertebral bone marrow fat fraction had a significant negative correlation with T2 values of nucleus pulposus’ T2 values (p < 0.001). However, the significant negative correlation was only found between T2 values of nucleus pulposus and adjacent vertebral bone marrow fat in Pfirrmann II–III, L1/2-L5/S1 level, and 40–49 years’ age groups. Pfirrmann grades of the intervertebral disc were positively correlated with adjacent vertebrae bone marrow fat fraction (p < 0.05). Conclusion Lumbar bone marrow fat deposition significantly increases during the early stages of intervertebral disc degeneration. Quantitative measurements of bone marrow fat deposition and water content of intervertebral discs have a predictive value and are an important supplement to the qualitative traditional classification strategies for the early stages of intervertebral disc degeneration. Keywords Lumbar disc degeneration . Quantitative MRI . Bone marrow fat
Abbreviations QMRI Quantitative magnetic resonance imaging IDEAL-IQ Iterative decomposition of water and fat with echo asymmetry and least squares estimation BMF Bone marrow fat IVD Intervertebral disc IVDD Intervertebral disc degeneration
FF VFF SFF IFF NP AAF PAF
Fat fraction Vertebral fat fraction (bone marrow fat fraction of the vertebra) Superior vertebral fat fraction Inferior vertebral fat fraction Nucleus pulposus Anterior annulus fibrosus Posterior annulus fibrosus
Yayun Ji and Weifeng Hong contributed equally to this work. * Liheng Ma [email protected]
Yuying Liang [email protected]
Yayun Ji [email protected] Weifeng Hong [email protected] Mouyuan Liu [email protected]
YongYan Deng [email protected] 1
Department of Medical Imaging, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou City 510080, Guangdong Province, China
Skeletal Radiol Table 1
Classification of disc degeneration [25]
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