Fibronectin Gene Expression in Human Adipose Tissue and Its Associations with Obesity-Related Genes and Metabolic Parame
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CLINICAL RESEARCH
Fibronectin Gene Expression in Human Adipose Tissue and Its Associations with Obesity-Related Genes and Metabolic Parameters Seoung Hee Lee & Hye Soon Park & Jung Ah Lee & Young Sook Song & Yeon Jin Jang & Jong-Hyeok Kim & Yeon Ji Lee & Yoonseok Heo
Published online: 24 December 2012 # Springer Science+Business Media New York 2012
Abstract Background Limited data are available on the in vivo expression of fibronectin, one of the main extracellular matrix components. We investigated the expression of fibronectin in abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) and the associations of leptin, adiponectin, and vaspin gene expression with metabolic parameters in obese women. S. H. Lee : H. S. Park (*) : J. A. Lee Department of Family Medicine, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-gu, Seoul 138-736, South Korea e-mail: [email protected] Y. S. Song : Y. J. Jang (*) Department of Physiology, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-gu, Seoul 138-736, South Korea e-mail: [email protected] J.-H. Kim Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-gu, Seoul 138-736, South Korea Y. J. Lee Department of Family Medicine, Inha University, College of Medicine, 7-206, Sinheung-dong 3-Ga, Jung-gu, Incheon 400-711, South Korea
Methods We recruited female subjects undergoing bariatric surgery for obesity (n024) and patients undergoing benign gynecological surgery as the control group (n023). We measured anthropometric variables, abdominal fat distribution, metabolic parameters, serum concentrations of leptin, adiponectin, and vaspin, and depot-specific mRNA expression of fibronectin, leptin, adiponectin, and vaspin. Results Fibronectin expression in both VAT and SAT was significantly lower in the obese group than in the control group. Fibronectin expression in both VAT and SAT were negatively correlated with body mass index or waist circumference, with higher prominence in VAT. In multiple regression analysis, fibronectin expression in both VAT and SAT was negatively correlated with serum leptin concentration. Fibronectin expression in VAT was negatively correlated with leptin expression in VAT. Additionally, fibronectin expression in SAT was negatively correlated with leptin expression in SAT and positively correlated with adiponectin expression in VAT and SAT. Conclusions We found significant negative associations between depot-specific fibronectin expression in human adipose tissue and obesity indices and obesity-related biomarkers. Our results suggest that fibronectin expression may contribute to obesity and metabolic dysregulation in humans. Keywords Obesity . Adipose tissue . Fibronectin . Leptin . Adiponectin
Introduction Y. Heo Department of General Surgery, Inha University, College of Medicine, 7-206, Sinheung-dong 3-Ga, Jung-gu, Incheon 400-711, South Korea
Growth of fat tissue involves both hyperplasia and hypertrophy of adipocytes and is
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