Changes in VGF and C3aR1 gene expression in human adipose tissue in obesity
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ORIGINAL ARTICLE
Changes in VGF and C3aR1 gene expression in human adipose tissue in obesity G. Koc1 · A. Soyocak1 · H. Alis2 · B. Kankaya2 · G. Kanigur1 Received: 7 July 2020 / Accepted: 28 November 2020 © The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2020
Abstract The VGF gene, which has been shown to be metabolically associated with energy balance, glucose homeostasis, insulin secretion process, and biological processes related to overeating, is prominent in relation to obesity. TLQP-21 neuropeptide, derived from the VGF, is considered to promote lipolysis by the beta-adrenergic pathway through targeting the C3aR1 receptor located in the adipocyte membrane. In this study, we aimed to measure the expression levels of the VGF and C3aR1 genes in the adipose tissue of obese subjects and individuals with normal weight determined based on body mass index (BMI), and to reveal the correlation of these levels with obesity. VGF and C3aR1 gene expression levels were measured using Real Time Polymerase Chain Reaction (RT PCR) in the visceral adipose tissue (VAT) samples of 52 obese patients (BMI ≥ 35 kg/m2) and 21 non-obese controls (BMI = 18.5–24.9 kg/m2). The results were statistically analyzed. The VGF expression was lower and the C3aR1 gene expression was higher in obese patients compared to the non-obese control group (p
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