Fibrosis evaluation of animal liver tissue by thermal conduction
Hepatic fibrosis is a condition that alters normal structure and composition of the liver. Long term, it leads to complications such as cirrhosis; an advanced stage of chronic liver diseases, which in turn can drive to hepatocarcinoma (liver cancer). Henc
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idad Autónoma Metropolitana Iztapalapa. Electrical Engineering Department, Mexico City, Mexico 2 Universidad Nacional Autónoma de México, UNAM, CCADET. Mexico City, Mexico 3 Unidad de Medicina Experimental, HIPAM, UNAM, Hospital General de México “Dr. Eduardo Liceaga” 4 Unidad de Investigación y Desarrollo Tecnológico, CCADET-UNAM-Hospital General de México “Dr. Eduardo Liceaga” 5 Dirección General, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán” Abstract— Hepatic fibrosis is a condition that alters normal structure and composition of the liver. Long term, it leads to complications such as cirrhosis; an advanced stage of chronic liver diseases, which in turn can drive to hepatocarcinoma (liver cancer). Hence, knowing the fibrosis degree is an important clinical data that can help in the prognosis and treatment of liver diseases. This work is focused in evaluating the thermal performance of 16 samples of rat liver tissue graded in different fibrosis degrees, as an alternate method to know how these properties change as the disease progresses. A heat sensor based on photo-thermal deflection was used. The thermal response was compared to the fibrosis degree in the METAVIR score, as evaluated by a group of experimented observers.
the physical properties that define an organ’s condition is very helpful to enhance our knowledge on some pathologies and to develop new resources to analyze them. Regarding hepatic fibrosis, recognition of the advance degree is very important to properly establish the prognosis and the therapeutic strategy. Due to the aforementioned, the focus of this work was to evaluate the thermal response of liver tissue from rats with different degrees of fibrosis, in order to better understand how hepatic tissue becomes progressively modified by this condition, so that it can contribute to a more precise diagnostic of the phases of liver diseases.
Keywords— Liver fibrosis, Thermal behavior, METAVIR score. I. INTRODUCTION
Hepatic fibrosis is a progressive change in the density and composition of the extracellular matrix in the liver parenchyma, which if persists leads to cirrhosis. Environmental and genetic factors have been described to influence its progress, as well as different methods to estimate it [1]. Cirrhosis is a condition where the structure and function of the liver are severely compromised [2]. Hepatic cirrhosis is a disorder with high mortality and morbidity rates. In Mexico, the reported cases of liver cirrhosis increased 7.8% from 2005 to 2006; morbidity is also reported to have increased 6%, hence becoming the third cause of death in the country. Cirrhosis is the second cause of death in the age group of 15-64 years, and the sixth in persons over 65 years [3]. There for the importance of developing auxiliary tools for evaluation and timely and precise progress of liver fibrosis in patient diagnosis. Characterization of hepatic tissue by its thermal properties is a useful method to study fibrosis, since it alters normal liver structure and function [4]. Thermal pro
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