Fluorescent Silicon Nanorods-Based Nanotheranostic Agents for Multimodal Imaging-Guided Photothermal Therapy
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ARTICLE
Cite as Nano-Micro Lett. (2019) 11:73 Received: 6 July 2019 Accepted: 25 August 2019 © The Author(s) 2019
https://doi.org/10.1007/s40820-019-0306-9
Fluorescent Silicon Nanorods‑Based Nanotheranostic Agents for Multimodal Imaging‑Guided Photothermal Therapy Mingyue Cui1, Sangmo Liu1, Bin Song1, Daoxia Guo1, Jinhua Wang1, Guyue Hu1, Yuanyuan Su1 *, Yao He1 * * Yuanyuan Su, [email protected]; Yao He, [email protected] Laboratory of Nanoscale Biochemical Analysis Institute of Functional Nano & Soft Materials (FUNSOM), and Jiangsu Key Laboratory for Carbon‑Based Functional Materials & Devices, Soochow University, 199 Ren’ai Road, Suzhou 215123, Jiangsu, People’s Republic of China
1
HIGHLIGHTS • A kind of multifunctional silicon-based theranostic agent is fabricated and exploited for imaging-guided tumor-targeted photothermal therapy. • The obtained gold nanoparticles-decorated fluorescent silicon nanorods featuring high photothermal conversion performance and good photothermal stability enable a total ablation of tumors and prolong the survival time of mice.
ABSTRACT The utilization of diagnosis to guide/aid
nanorods (Au@SiNRs), is fabricated and exploited for tumor-targeted multimodal imaging-guided pho‑
Ca2+
O
N
Si
Protein micelle
O
O H N O RGD
NH NH O HN
NH NH
Au@SiNRs AuNPs
RGD-PEG-Au@SiNRs mSH-PEG
Tumor Tissue NIR laser
SiNRs feature high photothermal conversion efficiency mal performance stays constant after five-cycle NIR
OH N HS
2
SiNRs C
HO HN
Step 2
Step 1
PO43−
tothermal therapy. In particular, the prepared Au@ (~ 43.9%) and strong photothermal stability (photother‑
HO
PEG and RGD functionalization Step 3
a kind of multifunctional silicon-based nanostructure, i.e., gold nanoparticles-decorated fluorescent silicon
AuNPs in situ growth
s NP
tion of tumor heterogeneity and complexity. Herein,
Ca2+
PO43−
Crystal growth and aggregation
Au
era of personalized medicine along with the recogni‑
PO43−
Ca2+
O
therapy procedures has shown great prospects in the
Active targeting
laser irradiation), making them high-performance agents for simultaneously photoacoustic and infrared
Tumor neovessels
thermal imaging. The Au@SiNRs are readily modi‑
fied with targeting peptide ligands, enabling an enhanced tumor accumulation with a high value of ~ 8.74% ID g−1. Taking advantages of these unique merits, the Au@SiNRs are superbly suitable for specifically ablating tumors in vivo without appreciable toxicity under the guidance of multimodal imaging. Typically, all the mice treated with the Au@SiNRs remain alive, and no distinct tumor recurrence is observed during 60-day investigation. KEYWORDS Gold nanoparticle; Fluorescent silicon nanorods; Nanotheranostic; Multimodal imaging; Photothermal therapy; Tumor target
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1 Introduction Along with tremendous advances in cancer nanomedicine, more challenges such as the complexity and heterogeneity of tumors are gradually realized [1, 2]. Using diagnosis to guide/aid therapy procedures w
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