Forensic parameters and genetic structure analysis of 30 autosomal InDels of the population in Freetown, Sierra Leone
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Forensic parameters and genetic structure analysis of 30 autosomal InDels of the population in Freetown, Sierra Leone Han Wang 1 & Foday Ambrose Marah 2 & Moses Moseray 3,4 & Moutanou Modeste Judes Zeye 5 & Ying Liu 5 & Jienan Li 5 & Lagabaiyila Zha 5,6 Received: 25 June 2020 / Accepted: 27 August 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract As the origin of modern humanity, African populations show high genetic diversity and are attracting increasing academic attention. However, populations living in West Africa have so far received less study and exploration. In this study, we analyze 30 insertion/ deletion (InDel) loci of 516 samples from Freetown, Sierra Leone, to evaluate the forensic properties and reveal the genetic structure in Freetown, Sierra Leone, West Africa. No significant linkage disequilibrium (LD) between 30 InDels was observed after the Bonferroni correction. The random match probability (RMP), the combined power of exclusion for duos (CPE duos), and the combined power of exclusion for trios (CPE trios) were 6.823 × 10−11, 0.9168, and 0.9731, respectively. Null alleles and off-ladder alleles were observed, suggesting that we should be cautious when using this kit for forensic caseworks in African populations. In the population comparison study, we found that the Freetown population is genetically closer to geographically distinct West Africans and has a closer genetic relationship with the Bantu-speaking populations than other African populations. Keywords Forensic genetics . InDels . The Freetown population
Introduction Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00414-020-02417-7) contains supplementary material, which is available to authorized users. * Jienan Li [email protected] * Lagabaiyila Zha [email protected] 1
Department of Clinical Diagnostic Centre, the Fifth Medical Centre, Chinese PLA (People’s Liberation Army) General Hospital, Beijing, People’s Republic of China
2
The GREY Bush Community Health Center, Grey Bush, Ascension-town, Sierra Leone
3
Joint Medical Unit, Freetown, Sierra Leone
4
Clinical Laboratory, 34 Military Hospital, Freetown, Sierra Leone
5
Department of Forensic Medicine, School of Basic Medical Sciences, Central South University, No172. Tongzipo Road, Changsha 410013, Hunan Province, People’s Republic of China
6
China-Africa Research Center of Infectious Diseases, Central South University, Changsha, Hunan, People’s Republic of China
Archaeological, fossil, and genetic data suggests that an African origin of modern humans and African populations have the highest levels of genetic diversity in the world [1, 2]. Sierra Leone is located on the Atlantic coast of West Africa, surrounded by Guinea to the north and east, and bordered by Liberia to the southeast, with a total area of 71,740 km2 and a population of 7,650,154 according to the 2018 census (https:// www.fmprc.gov.cn/web/gjhdq_676201/gj_676203/fz_677316/ 1206_678380/1206x0_678382/t9445.shtml; https://data
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