Frequency of nodular goiter and autoimmune thyroid disease in patients with polycystic ovary syndrome
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ORIGINAL ARTICLE
Frequency of nodular goiter and autoimmune thyroid disease in patients with polycystic ovary syndrome Cevdet Duran • Mustafa Basaran • Orkide Kutlu • Zehra Kucukaydin • Suleyman Bakdik • Ferda Sevimli Burnik • Uysaler Aslan • Sami Said Erdem Samil Ecirli
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Received: 24 October 2014 / Accepted: 5 December 2014 Ó Springer Science+Business Media New York 2014
Abstract Polycystic ovary syndrome (PCOS), and nodular and autoimmune thyroid diseases are frequently seen disorders. Previous studies reported conflicting results regarding possible association between PCOS and thyroid disorders. In this study, we investigated the frequency of autoimmune thyroid disease (AITD) and nodular goiter in patients with PCOS. Seventy-three PCOS patients and 60 age-matched controls were enrolled in the study. In PCOS group, body mass index values (27.45 ± 5.73 vs. 22.55 ± 3.78 kg/m2, p \ 0.001, respectively), systolic [110 mmHg (90–130) vs. 100 mmHg (90–140), p = 0.016, respectively] and diastolic (72.67 ± 6.52 vs. 66.42 ± 8.88 mmHg, p \ 0.001, respectively) blood pressure, waist circumference (86.27 ± 14.41 vs. 78.78 ± 8.87 cm, p \ 0.001, respectively), and homeostasis model assessment-insulin resistance (HOMA-IR) levels (2.96 ± 2.11 and 1.77 ± 0.83 p \ 0.001, respectively) were higher than controls.
However, thyroid nodule frequency was similar in both groups [22 (30.1 %) vs. 12 (20 %)], also thyroid gland volume was not significantly different [9.23 ml (3.08–32.40) vs. 8.52 ml (4.28–50.29)] among groups. The percentages of patients with thyroid parenchymal heterogeneity, positive anti-thyroid peroxidase, anti-thyroglobulin, and AITD were similar. Cases were reclassified according to the presence of thyroid nodule in which similar HOMA-IR levels were detected (median 2.39 and 1.89, p = 0.093, respectively) despite the fact that the group with nodules had higher mean age (26.5 (18–37) vs. 21 (18–34), p = 0.013, respectively). Similar ratios of thyroid nodule and AITD were found in patients with PCOS and controls. Keywords Polycystic ovary syndrome Thyroid nodule Autoimmune thyroid disease
Introduction C. Duran (&) F. S. Burnik Division of Internal Medicine, Endocrinology and Metabolism, Konya Training and Research Hospital, 42100 Konya, Turkey e-mail: [email protected] M. Basaran Z. Kucukaydin Division of Obstetrics and Gynecology, Konya Training and Research Hospital, Konya, Turkey O. Kutlu U. Aslan S. Ecirli Division of Internal Medicine, Konya Training and Research Hospital, Konya, Turkey S. Bakdik Division of Radiology, Konya Training and Research Hospital, Konya, Turkey S. S. Erdem Department of Biochemistry, Konya Training and Research Hospital, Konya, Turkey
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women and its prevalence is reported as 5–10 % worldwide [1–3]. The characteristics of this syndrome are hirsutism, hyperandrogenism, menstrual disturbance, and infertility. Obesity, impaired glucose tolerance, and insulin resistance are wellknown f
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