Methylenetetrahydrofolate reductase C677T gene polymorphism in turkish patients with polycystic ovary syndrome
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ORIGINAL ARTICLE
Methylenetetrahydrofolate reductase C677T gene polymorphism in turkish patients with polycystic ovary syndrome Muammer Karadeniz • Mehmet Erdogan • Ayhan Zengi • Zuhal Eroglu • Sadik Tamsel • Murat Olukman • Fusun Saygili • Candeger Yilmaz
Received: 12 April 2010 / Accepted: 28 June 2010 / Published online: 9 July 2010 Ó Springer Science+Business Media, LLC 2010
Abstract Higher Levels of Hcy are associated with several clinical conditions, among them non-insulin-dependent diabetes mellitus, endometrial dysplasia and hypertension with insulin resistance, and polycystic ovary syndrome. The purpose of this study was to investigate the serum homocystein levels and other metabolic parameters in relationship with the MTHFR C677T gene polymorphism in patients with PCOS. Our study included 86 young women with PCOS constituting the study group and 70 healthy women constituting the control group. Homocystein levels, metabolic, and hormonal parameters were measured, and genetic analysis of the MTHFR C677T gene polymorphism was performed in all the subjects. A statistically significant difference was observed in mean homocystein levels between patients with PCOS when compared to the control group. The MTHFR 677 CC genotypes had significantly higher proportions in the control group compared to the PCOS patients (v2 = 21.381, P \ 0.001). Our data show that homocystein levels were higher than normal
M. Karadeniz (&) M. Erdogan A. Zengi F. Saygili C. Yilmaz Endocrinology and Metabolism Disease, Ege University Medical School, 35100 Bornova, Izmir, Turkey e-mail: [email protected] Z. Eroglu Department of Medical Biology, Ege University Hospital, Bornova, Izmir, Turkey S. Tamsel Department of Radiology, Ege University Hospital, Bornova, Izmir, Turkey M. Olukman Department of Pharmacology, Ege University Hospital, Bornova, Izmir, Turkey
subjects in patients with PCOS and that the MTHFR C677T gene polymorphism does not influence homocystein levels of patients with PCOS. Keywords Hyperhomocysteinemia Methylenetetrahydrofolate reductase MTHFR C677T Polymorphism Polycystic ovary syndrome
Introduction Polycystic ovary syndrome (PCOS) is one of the most encountered endocrine malfunctions, which typically occurs with chronic anovulation and hyperandrogenism [1]. Almost 15% of women in reproductive age suffer from PCOS symptoms [2]. Cardiovascular diseases (CVD), dyslipidemia, and hypertension are seen more frequently in patients with PCOS than controls [3–5]. PCOS has also been reported to be associated with an increase in subclinical atherosclerotic diseases [5]. These findings suggest that women with PCOS may be at a higher risk for early-onset CVD. Given the high prevalence of PCOS in the female population, this disorder may potentially account for a significant proportion of atherosclerotic heart diseases observed in young women. The imbalance between homocystein (Hcy) production and metabolism might possibly due to demographic, genetic, nutritional, or metabolic factors that cause an abnormal i
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