From Molecular to Modular Tumor Therapy Tumors are Reconstructible C
The traditional problem of the poor presentability as well as diagnostic and therapeutic practicability of individual patient care is still unresolved. The present book aims at leading the reader (cancer researchers, pharmacologists, biologists) away―in a
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The Tumor Microenvironment Series Editor: Isaac P. Witz
For other titles published in this series, go to www.springer.com/series/7529
Albrecht Reichle Editor
From Molecular to Modular Tumor Therapy Tumors are Reconstructible Communicatively Evolving Systems
Editor Albrecht Reichle Department of Hematology and Oncology University Hospital of Regensburg 93042, Regensburg, Germany [email protected]
ISBN 978-90-481-9530-5 e-ISBN 978-90-481-9531-2 DOI 10.1007/978-90-481-9531-2 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2010935488 © Springer Science+Business Media B.V. 2010 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
Part I Therapy-Derived Systems Biology: A Pragmatic Communication Theory 1 Bridging Theory and Therapeutic Practice: From Generalized Disease Models to Particular Patients...................... Albrecht Reichle 2 Tumor Systems Need to be Rendered Usable for a New Action-Theoretical Abstraction: The Starting Point for Novel Therapeutic Options....................................................................... Albrecht Reichle 3 Principles of Modular Tumor Therapy.................................................... Albrecht Reichle and Gerhard C. Hildebrandt
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Part II Tumors Share Common Processes During Tumor Evolution: Communicative Aspects of a Situation’s Interpretation for Creating Systems-Directed Therapies 4 Cancer and Coagulation; Focusing on Tissue Factor and Heparanase............................................................................. Yona Nadir
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5 The Role of Mesenchymal Cells in Cancer: Contribution to Tumor Stroma and Tumorigenic Capacity.......................................... Ofer Shoshani and Dov Zipori
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6 Shaping Tumor Associated Macrophages: The Role of NF-kB............. Robin Soper and Thorsten Hagemann
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7 The Metabolic Achilles Heel: Tumor Cell Metabolism as Therapeutic Target................................................................................ 111 Eva Gottfried, Katrin Peter, and Marina P. Kreutz v
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Contents
8 Could Be Systems-Directed Therapy Approaches Promising in Glioblastoma Patients?..................................................... 133 Oliver Grauer and Peter Hau Part III Systems-Relevant Molecular and Cellular Targets: Implementation of Modular ‘Knowledge’ 9 Functional Impacts of Signal Integration: Regulation of Inflammation-Related Transcription Factors by Heterotrimeric G Proteins................................................................. 161 Wendy Wing Shan Yeung, Maurice
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