Renal Tumors of Childhood Biology and Therapy
This book provides a comprehensive overview of the biological basis of renal tumors in childhood and the clinical approaches to their treatment. Recent advances in our understanding of the molecular genetics of Wilms and other renal tumors are placed in t
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Kathy Pritchard-Jones Jeffrey S. Dome Editors
Renal Tumors of Childhood Biology and Therapy
Pediatric Oncology
Kathy Pritchard-Jones • Jeffrey S. Dome Editors
Renal Tumors of Childhood Biology and Therapy
Editors Kathy Pritchard-Jones Department of Developmental Biology and Cancer Institute of Child Health University College London London UK
Jeffrey S. Dome Children's National Medical Center Center for Cancer and Blood Disorders Washington, District of Columbia USA
ISSN 1613-5318 ISSN 2191-0812 (electronic) ISBN 978-3-662-44002-5 ISBN 978-3-662-44003-2 (eBook) DOI 10.1007/978-3-662-44003-2 Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2014957753 © Springer-Verlag Berlin Heidelberg 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher's location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
Astonishing progress has been made in pediatric oncology. More than 80 % of children with acute lymphocytic leukemia now survive; the disease was considered incurable a scant five or six decades ago [1]. Moreover, treatment intensity is now modified according to well-defined clinical and more sophisticated risk factors. This progress has been mirrored in the solid malignant tumors of childhood, notably in the case of Wilms’ tumor (WT). The long-term cure rate is in the 90 % range,
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