Frugal Innovation in Bioengineering for the Detection of Infectious Diseases

This book introduces readers to the concept of 'frugal innovation' and describes novel low-cost technologies that aid in diagnosing infectious diseases. Rapidly deployable, portable, and affordable diagnostic tools have the potential to tremendously benef

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gal Innovation in Bioengineering for the Detection of Infectious Diseases

Frugal Innovation in Bioengineering for the Detection of Infectious Diseases

Arvind K. Chavali  •  Ramesh Ramji Editors

Frugal Innovation in Bioengineering for the Detection of Infectious Diseases

Editors Arvind K. Chavali Yale University New Haven, CT, USA

Ramesh Ramji Illumina San Diego, CA, USA

ISBN 978-3-319-66645-7    ISBN 978-3-319-66647-1 (eBook) https://doi.org/10.1007/978-3-319-66647-1 Library of Congress Control Number: 2017958641 © Springer International Publishing AG 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Frugal Bioengineering: Preface and Introduction

Recent advances in biomedical engineering have paved the way for the development of low-cost technologies that can aid in diagnosing diseases or improving global health outcomes. Rapidly deployable, portable, and low-cost diagnostic platforms have the potential to impact millions of people around the world, especially those living in extreme poverty. In 2014, Manu Prakash and colleagues at Stanford University invented an ultralow-cost microscope, which they termed “foldscope,” to be used in the field in resource-poor settings [1]. Coupling principles of optical design and origami, the microscope was able to achieve over 2000× magnification with submicron resolution all the while costing