Furosemide

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Nephrocalcinosis: case report A 47-year-old woman developed nephrocalcinosis during treatment with furosemide for the reduction of bilateral lower leg oedema. The woman with longstanding bilateral lower leg oedema, presented to clinic for evaluation. She had been receiving furosemide 10 mg/day for reduction of the oedema for ten years [route not stated]. Examinations showed subcutaneous fat but no oedema in the legs. Abdominal ultrasound showed linear hyperechoic corticomedullary junctions in both the kidneys. Abdominal CT scan demonstrated linear high-density lesions along the renal corticomedullary junctions of both kidneys. Based on the examination, nephrocalcinosis secondary to prolonged use of furosemide was considered. Laboratory examinations showed normal levels of serum calcium, phosphate and creatinine with low potassium level at 3.5 mEq/L, and low urinary pH at 4.5 [duration of treatment to reaction onset and outcome not stated]. Oda Y, et al. Linear Calcification along the Renal Corticomedullary Junction. Internal Medicine 59: 1781, No. 14, 15 Jul 2020. Available from: URL: http://doi.org/10.2169/ 803504495 internalmedicine.4414-20

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