Ganciclovir
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Leucopenia: case report A 47-year-old woman developed leucopenia after receiving ganciclovir for the treatment of infection. The woman was admitted due to autoimmune hepatitis, liver cirrhosis and upper gastrointestinal haemorrhage. After admission, fever and coughing were reported, with jaundice observed and a WBC of 7.1 × 109/L. She received cefoperazone, sulbactam and metronidazole for 5 days, however infection persisted. Her body temperature increased from 38.5 to 39.5°C and coughing worsened. She was then given ganciclovir [Hepuxin] 0.25 g twice daily. Her WBC decreased progressively to 0.8 × 109/L during treatment and ganciclovir was discontinued shortly after [time to reaction onset not stated]. The woman began treatment with recombinant human granulocyte colony stimulating factor and her WBC count normalised 3 days later. Treatment was discontinued and tests taken during the next 10 days confirmed normal counts. Author comment: According to the methodology adopted by the National Drug Adverse Effect Supervision Centre, the bone marrow suppression in this case is very probably caused by ganciclovir. Pang X-Y, et al. Ganciclovir-induced serious leukocytopenia: 1 case reports. Chinese Journal of New Drugs 18: 1918, No. 19, 15 Oct 2009 [Chinese; 803006627 summarised from a translation] - China
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Reactions 6 Mar 2010 No. 1291
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