Gene- and Cell-Based Treatment Strategies for the Eye

In this book, leading experts provide detailed descriptions of the exciting treatments that are expected to become part of the ophthalmologist’s arsenal within the next 10–20 years. The treatments discussed relate to a wide variety of conditions, includin

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Elizabeth P. Rakoczy Editor

Gene- and CellBased Treatment Strategies for the Eye

Essentials in Ophthalmology Series Editor Arun D. Singh

For further volumes: http://www.springer.com/series/5332

Elizabeth P. Rakoczy Editor

Arun D. Singh Series Editor

Gene- and Cell-Based Treatment Strategies for the Eye

Editor Elizabeth P. Rakoczy Department of Molecular Ophthalmology Centre for Ophthalmology and Visual Sciences The University of Western Australia Crawley Western Australia Australia Series Editor Arun D. Singh Department of Ophthalmic Oncology Cole Eye Institute Cleveland Clinic Cleveland, Ohio USA

ISSN 1612-3212 ISBN 978-3-662-45187-8 ISBN 978-3-662-45188-5 DOI 10.1007/978-3-662-45188-5 Springer Heidelberg New York Dordrecht London

(eBook)

Library of Congress Control Number: 2014958086 © Springer-Verlag Berlin Heidelberg 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher's location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Preface

This book tells the great story of how the treatment of eye disease might change in the near future. The reader is explained how gene and cell therapies work and the difficulties scientists face in developing new technologies (experimental details, funding, approvals, ownership). The leaders of the field give a rare insight into the development of treatments for Leber’s con