Gene Function Analysis
The determination of protein function has been a major goal of molecular biology since the founding of the discipline. However, as we learn more about gene function, we discover that the context within which a gene is expressed controls the specific funct
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Michael F. Ochs Editor
Gene Function Analysis Second Edition
METHODS
IN
M O L E C U L A R B I O LO G Y ™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Gene Function Analysis Second Edition
Edited by
Michael F. Ochs Department of Mathematics & Statistics, The College of New Jersey, Ewing, NJ, USA
Editor Michael F. Ochs Department of Mathematics & Statistics The College of New Jersey Ewing, NJ, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) ISBN 978-1-62703-720-4 ISBN 978-1-62703-721-1 (eBook) DOI 10.1007/978-1-62703-721-1 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2013950909 © Springer Science+Business Media, LLC 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Cover illustration: The image on the cover comprises a composite of mCherry staining showing expression in zebrafish using the gene trap of Chapter 19, Figure 3, and a network deduced computationally in Chapter 11, Figure 15. The integration of computational and experimental methods will mark future development in gene function analysis. Images for composition were provided by Dr. Wenbiao Chen of the Vanderbilt University School of Medicine and Dr. Ilya Serebriiskii of the Fox Chase Cancer Center. Printed on acid-free pape
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