Genes in the pathway of tooth mineral tissues and dental caries risk: a systematic review and meta-analysis
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REVIEW
Genes in the pathway of tooth mineral tissues and dental caries risk: a systematic review and meta-analysis Luiz Alexandre Chisini 1 & Mariana Gonzalez Cademartori 1 & Marcus Cristian Muniz Conde 2 & Luciana Tovo-Rodrigues 1 & Marcos Britto Correa 1 Received: 6 July 2019 / Accepted: 6 November 2019 # Springer-Verlag GmbH Germany, part of Springer Nature 2019
Abstract Objectives To perform a systematic review of the literature, investigating the influence of tooth mineral tissues genes on dental caries. Materials and methods Five databases were searched. Only human studies with cross-sectional, longitudinal, and case-control design were included. Meta-analysis was performed for each polymorphism, providing allele and genotype estimates. A metaanalysis was performed, pooling several polymorphisms for each gene. A Funnel Plot and Egger’s test were also performed. Results A total of 1124 records were found. Of these, 25 papers were included in the systematic review and 18 in the metaanalysis. Most of the studies (52%) were of medium quality. With regard to the allele analysis, the T allele of rs134136 (TFIP11) (OR 1.51; 95%CI 1.02–2.22) showed an association with high experience of caries and the summarization of polymorphisms investigated in the TFIP11 gene, after exclusion of SNP linkage disequilibrium, showed an association with caries experience (OR 1.64; 95%CI 1.08–2.50). An analysis of the homozygous genotype did not show any significant association. The pooled SNPs of AMBN showed associations with caries (OR 0.45; 95%CI 0.29–0.72). The pooled polymorphisms of AMELX were associated with caries experience (OR 1.78; 95%CI 1.23–2.56). In the analysis of the homozygous genotype, no SNP showed a significant association. Egger’s test showed no significant publication bias for all models (p > 0.05). Conclusion The present findings showed that the genes TFIP11, AMBN, and AMELX play an important role in dental caries. Clinical relevance Several single nucleotide polymorphisms related to the genes in the formation of tooth mineral are linked to the occurrence of dental caries, and these genes have proved to be important for an explanation of differences in the risk of dental caries. Keywords Polymorphisms . Dental caries . Mineral tissues . Genetic . Gene
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00784-019-03146-x) contains supplementary material, which is available to authorized users. * Marcos Britto Correa marcosbrittocorrea@hotmail.com
Luciana Tovo-Rodrigues luciana.tovo@gmail.com
Luiz Alexandre Chisini alexandrechisini@gmail.com
1
Federal University of Pelotas, 457, Gonçalves Chaves St. 5th floor, Pelotas, RS 96015-560, Brazil
Mariana Gonzalez Cademartori marianacademartori@gmail.com
2
University of Vale do Taquari, 171, Avelino Talini St, Lajeado, RS 95914-014, Brazil
Marcus Cristian Muniz Conde marcus.conde@univates.br
Clin Oral Invest
Introduction
Methods
Dental caries is a chronic disease with high global prevalence [1]. About 2.4 billion
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