Genetic testing on products of conception and its relationship with body mass index
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REPRODUCTIVE PHYSIOLOGY AND DISEASE
Genetic testing on products of conception and its relationship with body mass index Linlin Wang 1 & Jiawei Xu 1 & Wenbin Niu 1 & Linli Hu 1 & Yile Zhang 1 & Yingpu Sun 1 Received: 7 April 2020 / Accepted: 2 June 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose The study aimed to investigate the relationship between elevated maternal body mass index (BMI) and foetal chromosomal aberrations by performing single-nucleotide polymorphism (SNP) array-based genetic testing on products of conception (POC). Methods We retrospectively reviewed the data for 1068 assisted reproductive technology (ART)-conceived POC originated from 1068 patients with early spontaneous miscarriage. First, all types of chromosomal abnormalities were defined. Then, the baseline characteristics, including maternal age, BMI, thyroid-stimulating hormone (TSH), gestational age, fertilization method, reasons for fertility treatment, embryo transfer (ET) cycle, stage of embryo development and the embryo morphology grade, were compared between chromosomally normal and abnormal POC groups. Finally, a multivariate logistic regression model was used to analyse various factors affecting the foetal chromosomal abnormality rate. Results The SNP array results showed that 45.3% (484/1068) of POC were chromosomally normal and that 54.7% (584/1068) of POC presented chromosomal abnormalities. Of these 584 chromosomally abnormal POC, 388 (66.4%) were trisomy, 42 (7.2%) had a monosomy, 68 (11.6%) were found with segmental aneuploidy, 46 (7.9%) were mosaic, 28 (4.8%) were identified as polyploidy and 12 (2.1%) were euploid samples with uniparental disomy (UPD). Multivariate logistic regression results showed that the risk of miscarrying chromosomally abnormal POC increased 1.424-fold in women with normal BMI compared to women with an elevated BMI (≥ 25 kg/m2) (OR = 1.424, 95% CI = 1.074–1.888, p = 0.014). Conclusion Women with an elevated BMI (≥ 25 kg/m2) are more likely to miscarry chromosomally normal POC. Keywords Overweight/obese . Genetic test . Miscarriage . Products of conception (POC)
Introduction Obesity is currently regarded as a worldwide epidemic and is widely reported to be associated with many diseases [1, 2]. The adverse impacts of obesity on child-bearing women are well recognized [3, 4]. For women who conceived naturally,
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10815-020-01849-9) contains supplementary material, which is available to authorized users. * Yingpu Sun [email protected] 1
Reproductive Medical Centre, Henan Province Key Laboratory for Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Number 1, Eastern Jianshe Road, Erqi district, Zhengzhou City 450002, Henan Province, China
studies have shown that overweight/obese women had a 1.2fold increased risk of experiencing a spontaneous miscarriage and a 3.5-fold increased risk of recurrent miscarriage compared with their age-ma
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