Effects of plant protein and animal protein on lipid profile, body weight and body mass index on patients with hyperchol
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ORIGINAL ARTICLE
Effects of plant protein and animal protein on lipid profile, body weight and body mass index on patients with hypercholesterolemia: a systematic review and meta‑analysis Hang Zhao1 · An Song2 · Chong Zheng3 · Mengdi Wang4 · Guangyao Song1 Received: 30 January 2020 / Accepted: 4 April 2020 © Springer-Verlag Italia S.r.l., part of Springer Nature 2020
Abstract Objective We conducted a meta-analysis on the effect of plant protein or animal protein on body weight (BW), body mass index (BMI) and blood lipid profiles in patients with hypercholesterolemia. Materials and methods We used subject and free words to search PubMed, Embase and Cochrane Library databases. The risk-of-bias evaluation tool was used to assess literature quality. Data merging and statistical analyses were carried out using Review Manager 5.3 and Stata 13.0. All indicators were expressed as the mean difference (MD) and 95% confidence interval (95% CI). The heterogeneity test was conducted according to I2 and Q tests. We used Egger’s test to evaluate publication bias quantitatively. Results This was a meta-analysis of intervention trials. Thirty-two studies (1562 patients) were included. The quality of the included studies was acceptable. Compared with consumption of animal protein, plant protein reduced total cholesterol (TC) (MD = − 0.19 mmol/L, 95% CI − 0.26, − 0.12), triglyceride (MD = − 0.07 mmol/L, 95% CI − 0.13, − 0.02), low-density lipoprotein cholesterol (LDL-C) (MD = − 0.19 mmol/L, 95% CI − 0.26, − 0.13), very low-density lipoprotein cholesterol (MD = − 0.05 mmol/L, 95% CI − 0.09, − 0.01), TC/LDL-C ratio (MD = − 0.17, 95% CI − 0.32, − 0.02) and LDL-C/HDL-C ratio (MD = − 0.20, 95% CI − 0.33, − 0.06) significantly and increased high-density lipoprotein cholesterol (HDL-C) (MD = 0.03 mmol/L, 95% CI 0.01, 0.06) levels, but had no effect on BW (MD = − 0.41 kg, 95% CI − 2.14, 1.33) or BMI (MD = 0.11 kg/m2, 95% CI − 0.51, 0.73). Conclusion Compared with animal protein, consumption of plant protein could improve lipid profile in patients with hypercholesterolemia. Keywords Plant protein · Animal protein · Hypercholesterolemia · Lipid
Introduction Managed By Massimo Porta. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00592-020-01534-4) contains supplementary material, which is available to authorized users. * Guangyao Song [email protected] 1
Endocrinology Department, Hebei General Hospital, 348, Heping West Road, Shijiazhuang 050051, Hebei, China
Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing 100730, China
2
In general, it is thought that hypercholesterolemia increases the incidence and mortality of cardiovascular and cerebrovascular diseases significantly [1], so it is important to treat/ 3
Pediatric Orthopaedics, Shijiazhuang the
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