Genetics of Melanoma
This book discusses the molecular, biological, pathological, and clinical aspects of melanoma, with special emphasis in the new concepts of melanoma genetics. A multidisciplinary group of experts in Genetics, Dermatology, Pathology, and Melanoma Medical O
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Carlos A. Torres-Cabala Jonathan L. Curry Editors
Genetics of Melanoma
Cancer Genetics
More information about this series at http://www.springer.com/series/7706
Carlos A. Torres-Cabala • Jonathan L. Curry Editors
Genetics of Melanoma
Editors Carlos A. Torres-Cabala MD Anderson Cancer Center The University of Texas Houston, TX, USA
Jonathan L. Curry MD Anderson Cancer Center The University of Texas Houston, TX, USA
ISBN 978-1-4939-3552-9 ISBN 978-1-4939-3554-3 DOI 10.1007/978-1-4939-3554-3
(eBook)
Library of Congress Control Number: 2016936786 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
Dedication by Carlos A. Torres-Cabala To E. Maria Luisa, my wife, and Adriana, my beautiful daughter, whom I love and admire. To Luis and Consuelo, my parents, to whom I owe everything that I am and want to be. To Carmen, Eliana, and José Luis, my siblings, and their families, who are always there for me. Dedication by Jonathan L. Curry To my amazing wife Choladda and our beautiful children Rachel and Nathanial, I am blessed to have a loving family. To my parents James and Carol, without their love, sacrifice, and support my dreams would not have been possible. To my sister Elizabeth and her family Paul and Jennifer, who have always given me their love and support.
Preface
Advances in molecular technologies and high-throughput sequencing testing platforms have brought an impressive amount of discoveries in the field of melanoma genetics that have changed our approach in understanding the pathogenesis and treatment of this lethal disease. Knowledge of the genetic aberrations in melanoma is essential for the diagnosis and appropriate selection of patients who may benefit from personalized targeted therapeutic agents. This book is intended to span the basic molecular, genetic, e
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