Melanoma Development Molecular Biology, Genetics and Clinical Applic
The book provides comprehensive insights into molecular changes in malignant melanoma. The general mechanisms of melanoma growth and development are described, as well as new research findings. Our current knowledge on the molecules involved in cell trans
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Anja Bosserhoff (Editor)
Melanoma Development Molecular Biology, Genetics and Clinical Application
Editor Prof. Dr. Anja Bosserhoff, PhD University of Regensburg Institute of Pathology Molecular Pathology Franz-Josef-Strauss-Allee 11 93053 Regensburg Germany [email protected]
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machines or similar means, and storage in data banks. Product Liability: The publisher can give no guarantee for all the information contained in this book. This does also refer to information about drug dosage and application thereof. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. © Springer-Verlag/Wien 2011 SpringerWienNewYork is part of Springer Science+Business Media springer.at Typesetting: SPi-Global, Pondicherry, India Cover design: WMXDesign, GmbH Printed on acid-free and chlorine-free bleached paper SPIN: 80014390 With 42 (partly coloured) Figures Library of Congress Control Number: 2011929930
ISBN 978-3-7091-0370-8 e-ISBN 978-3-7091-0371-5 DOI 10.1007/978-3-7091-0371-5 SpringerWienNewYork
Preface
This book, Melanoma Development: Molecular Biology, Genetics and Clinical Application, provides a comprehensive insight into the molecular changes of malignant melanoma and implications for therapeutic approaches. It summarizes the current knowledge on the nature of melanoma and is intended to provide a broad overview of major aspects of the molecular biology of melanoma. The chapters that comprise this book review what is currently known about the molecular basis of melanoma development and progression. The introduction gives a brief overview of the clinical nature of melanoma, and then general mechanisms of melanoma growth and development, as well as new research findings, are discussed. It addresses different molecular aspects of melanocyte and melanoma biology, from embryology to therapies. Through this comprehensive approach, it provides a cohesive view of melanoma biology that may serve as a source of information and starting point for future investigations, hopefully leading to more rapid clinical breakthroughs. By summarizing the newest data and presenting upcoming areas of research in the field, the book will be a valuable reference for biologists, basic scientists, and physicians working in the important fields of melanoma, cancer research, therapy, dermatology, and surgery. Our current knowledge and future understanding of the molecular mechanisms involved in cell transformation and tumor progression will soon lead to sophisticated targeted therapies. I am grateful to
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