Genome Stability and Human Diseases
Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic v
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SUBCELLULAR BIOCHEMISTRY SERIES EDITOR J. ROBIN HARRIS, University of Mainz, Mainz, Germany
ASSISTANT EDITORS P.J. QUINN, King’s College London, London, U.K.
Recent Volumes in this Series Volume 33 Bacterial Invasion into Eukaryotic Cells Tobias A. Oelschlaeger and Jorg Hacker Volume 34 Fusion of Biological Membranes and Related Problems Edited by Herwig Hilderson and Stefan Fuller Volume 35 Enzyme-Catalyzed Electron and Radical Transfer Andreas Holzenburg and Nigel S. Scrutton Volume 36 Phospholipid Metabolism in Apoptosis Edited by Peter J. Quinn and Valerian E. Kagan Volume 37 Membrane Dynamics and Domains Edited by P.J. Quinn Volume 38 Alzheimer’s Disease: Cellular and Molecular Aspects of Amyloid beta Edited by R. Harris and F. Fahrenholz Volume 39 Biology of Inositols and Phosphoinositides Edited by A. Lahiri Majumder and B.B. Biswas Volume 40 Reviews and Protocols in DT40 Research Edited by Jean-Marie Buerstedde and Shunichi Takeda Volume 41 Chromatin and Disease Edited by Tapas K. Kundu and Dipak Dasgupta Volume 42 Inflammation in the Pathogenesis of Chronic Diseases Edited by Randall E. Harris Volume 43 Subcellular Proteomics Edited by Eric Bertrand and Michel Faupel Volume 44 Peroxiredoxin Systems Edited by Leopold Flohd J. Robin Harris Volume 45 Calcium Signalling and Disease Edited by Ernesto Carafoli and Marisa Brini Volume 46 Creatine and Creatine Kinase in Health and Disease Edited by Gajja S. Salomons and Markus Wyss Volume 47 Molecular Mechanisms of Parasite Invasion Edited by Barbara A. Burleigh and Dominique Soldati-Favre Volume 48 The Coronin Family of Proteins Edited by Christoph S. Clemen, Ludwig Eichinger and Vasily Rybakin Volume 49 Lipids in Health and Disease Edited by Peter J. Quinn and Xiaoyuan Wang Volume 50 Genome Stability and Human Diseases Edited by Heinz Peter Nasheuer
Heinz Peter Nasheuer Editor
Genome Stability and Human Diseases
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Editor Heinz Peter Nasheuer National University of Ireland, Galway Galway Ireland
ISBN 978-90-481-3470-0 e-ISBN 978-90-481-3471-7 DOI 10.1007/978-90-481-3471-7 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2009941695 © Springer Science+Business Media B.V. 2010 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
This review book is dedicated to Dr. Teresa Wang the Klaus-Bensch Professor of Pathology Stanford University, California, to celebrate her life-long achievements in the fields of Genome Stability and Cell Cycle Regulation
Preface
Since the discovery of the DNA structure by Crick, Franklin, Watson and Wilkins in 1953 and even before researchers ha
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